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Designing modulators of PI 3-kinase delta (PI3Kdelta) for the treatment of haematological malignancies

Designing modulators of PI 3-kinase delta (PI3Kdelta) for the treatment of haematological malignancies
设计用于治疗血液恶性肿瘤的 PI 3 激酶 δ (PI3Kdelta) 调节剂
批准号：
MC_PC_MR/S02607X/1
负责人：
Bart Vanhaesebroeck
金额：
$7.55万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2019
资助国家：
英国
项目状态：
已结题
起止时间：
2019 至 --
来源：
https://gtr.ukri.org/projects?ref=MC_PC_MR%2FS02607X%2F1
关键词：
DesigningmodulatorsPIkinasedelta

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中文摘要
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英文摘要
This proposal is aimed at creating medicines that can control a protein called PI3Kdelta, for use in the treatment of blood cancers such as acute lymphoblastic leukaemia (ALL). It is based on clinical insight provided by our team, who are treating patients with this disease and recognise the need for improved therapies. We discovered PI3Kdelta and have long-term expertise on this molecule. We believe we have found news ways to modulate PI3Kdelta to treat leukaemia, and would now like to turn these concepts into a medicine, with the help of AstraZeneca.
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会议论文
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海外基金