Molecular drivers & predictors of pregnancy complications & future health

分子驱动器

• 批准号: MC_UU_00032/5
• 金额: $ 232.67万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00032%2F5
• 关键词: Molecular; drivers; predictors; pregnancy; complications

The aim of our programme is to complete research that will improve the care and health of women and their babies as they go through pregnancy and into the postnatal period. The key issues that we will address are: 1) Improving the treatment of pregnancy complications such as gestational diabetes and pre-eclampsia; 2) Determining the effects of treatments that women might be on before they become pregnant, such as treatments for epilepsy, depression or asthma, on their pregnancy health and their babies health; 3) Improving antenatal care so that monitoring is tailored to differences between women in their likelihood of having a healthy pregnancy or experiencing a pregnancy complication; 4) Improving postnatal care by identifying which women should be assessed for health problems such as diabetes, heart disease and depression after pregnancy, and when these women should be seen and what assessments and treatments should be used; 5) Understanding the relationship between having two or more chronic health problems and pregnancy complications. To do this research we will use large datasets that include information on women’s health and behaviours before, during and after pregnancy as well as genetic and molecular information, such as blood protein levels. We will work with obstetricians, midwives, women and couples, and policy makers to make sure our research improves pregnancy and postnatal health.

我们方案的目的是完成研究，改善妇女及其婴儿在怀孕和产后期间的护理和健康。我们将解决的关键问题是：1）改善妊娠并发症的治疗，如妊娠糖尿病和先兆子痫; 2）确定妇女在怀孕前可能接受的治疗的影响，如癫痫，抑郁症或哮喘的治疗，对她们的怀孕健康和婴儿的健康; 3）改善产前护理，以便根据妇女在健康怀孕或出现妊娠并发症的可能性方面的差异进行监测; 4）改善产后护理，确定哪些妇女应该接受糖尿病、心脏病和怀孕后抑郁症等健康问题的评估，以及何时应该对这些妇女进行评估和治疗; 5）了解有两个或两个以上的慢性健康问题和妊娠并发症之间的关系。为了进行这项研究，我们将使用大型数据集，其中包括有关妇女在怀孕前、怀孕期间和怀孕后的健康和行为的信息，以及遗传和分子信息，如血液蛋白水平。我们将与产科医生，助产士，妇女和夫妇以及政策制定者合作，以确保我们的研究改善怀孕和产后健康。

项目成果

Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes.

• DOI: 10.1186/s12916-023-03167-0
• 发表时间: 2024-01-29
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Borges, Maria Carolina;Clayton, Gemma L.;Freathy, Rachel M.;Felix, Janine F.;Fernandez-Sanles, Alba;Soares, Ana Goncalves;Kilpi, Fanny;Yang, Qian;Mceachan, Rosemary R. C.;Richmond, Rebecca C.;Liu, Xueping;Skotte, Line;Irizar, Amaia;Hattersley, Andrew T.;Bodinier, Barbara;Scholtens, Denise M.;Nohr, Ellen A.;Bond, Tom A.;Hayes, M. Geoffrey;West, Jane;Tyrrell, Jessica;Wright, John;Bouchard, Luigi;Murcia, Mario;Bustamante, Mariona;Chadeau-Hyam, Marc;Jarvelin, Marjo-Riitta;Vrijheid, Martine;Perron, Patrice;Magnus, Per;Gaillard, Romy;Jaddoe, Vincent W. V.;Lowe, William L.;Feenstra, Bjarke;Hivert, Marie-France;Sorensen, Thorkild I. A.;Haberg, Siri E.;Serbert, Sylvain;Magnus, Maria;Lawlor, Deborah A.
• 通讯作者: Lawlor, Deborah A.

Time-sensitive testing pressures and COVID-19 outcomes: are socioeconomic inequalities over the first year of the pandemic explained by selection bias?

• DOI: 10.1186/s12889-023-16767-5
• 发表时间: 2023-09-26
• 期刊: BMC PUBLIC HEALTH
• 影响因子: 4.5
• 作者: Carter, Alice R.;Clayton, Gemma L.;Borges, M. Carolina;Howe, Laura D.;Hughes, Rachael A.;Smith, George Davey;Lawlor, Deborah A.;Tilling, Kate;Griffith, Gareth J.
• 通讯作者: Griffith, Gareth J.

Identifying metabolic features of colorectal cancer liability using Mendelian randomization

使用孟德尔随机化识别结直肠癌易感性的代谢特征

• DOI: 10.7554/elife.87894.3
• 发表时间: 2023
• 期刊: eLife
• 影响因子: 7.7
• 作者: Hazelwood E

Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.

• DOI: 10.1186/s12916-022-02685-7
• 发表时间: 2023-01-11
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Alfano, Rossella;Zugna, Daniela;Barros, Henrique;Bustamante, Mariona;Chatzi, Leda;Ghantous, Akram;Herceg, Zdenko;Keski-Rahkonen, Pekka;de Kok, Theo M.;Nawrot, Tim S.;Relton, Caroline L.;Robinson, Oliver;Roumeliotaki, Theano;Scalbert, Augustin;Vrijheid, Martine;Vineis, Paolo;Richiardi, Lorenzo;Plusquin, Michelle
• 通讯作者: Plusquin, Michelle

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.

• DOI: 10.1186/s12916-023-03223-9
• 发表时间: 2024-01-25
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Hernaez, Alvaro;Skara, Karoline H.;Page, Christian M.;Mitter, Vera R.;Hernandez, Marta H.;Magnus, Per;Njolstad, Pal R.;Andreassen, Ole A.;Corfield, Elizabeth C.;Havdahl, Alexandra;Naess, Oyvind;Brumpton, Ben;Asvold, Bjorn Olav;Lawlor, Deborah A.;Fraser, Abigail;Magnus, Maria Christine
• 通讯作者: Magnus, Maria Christine