Mechanism and regulation of chromosome replication

染色体复制的机制和调控

• 批准号: MC_UU_00035/3
• 负责人: Ian Adams
• 金额: $ 371.43万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00035%2F3
• 关键词: Mechanism; regulation; chromosome; replication

Our research is trying to find out how we pass on the right number of chromosomes to our children. Mistakes in this process are very common in humans and can cause miscarriage and Down's Syndrome. We know that these mistakes are more common in a mother’s eggs than in a father’s sperm, and are much more common in eggs of older mothers. We also know that genetic mutations can cause chromosome behaviour in developing eggs and sperm to be so severely affected that people with these mutations are infertile.The behaviour of the chromosomes in developing eggs and sperm is difficult to study in humans, therefore we will create new genetically modified mice to help us study why the wrong number of chromosomes are often passed on to our children and how this is affected by ageing. We will also create new genetically modified mice to help us understand the type of mutations that can affect chromosome behaviour in developing eggs and sperm severely enough to cause infertility. We hope that this research will help us develop future approaches to improve chromosome behaviour in developing sperm and eggs and reduce the amount of genetic disease passed on to our children.

我们的研究试图找出我们如何将正确数量的染色体传给我们的孩子。这个过程中的错误在人类中非常常见，可能导致流产和唐氏综合症。我们知道这些错误在母亲的卵子中比在父亲的精子中更常见，并且在年长母亲的卵子中更常见。我们还知道，基因突变会严重影响卵子和精子发育过程中的染色体行为，从而导致患有这些突变的人不育。人类卵子和精子发育过程中的染色体行为很难研究，因此我们将创造新的转基因小鼠，以帮助我们研究为什么错误的染色体数量经常传递给我们的孩子，以及这是如何受到衰老的影响。我们还将创造新的转基因小鼠，以帮助我们了解突变类型，这些突变可能会严重影响发育中的卵子和精子的染色体行为，从而导致不育。我们希望这项研究将有助于我们开发未来的方法来改善精子和卵子发育中的染色体行为，并减少遗传疾病传给我们孩子的数量。

项目成果

Computational Tools for the Analysis of Meiotic Prophase I Images

• DOI: 10.1101/2023.11.15.567191
• 发表时间: 2024-03
• 期刊: bioRxiv
• 作者: James H. Crichton;I. Adams