Dissecting inositol pyrophosphates signalling

解析肌醇焦磷酸信号传导

• 批准号: MC_UU_12018/4
• 负责人: Adolfo Saiardi
• 金额: $ 115.7万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12018%2F4
• 关键词: Dissecting; inositol; pyrophosphates; signalling

My research is focused on the study of inositol phosphates, a large family of small molecules that regulate many essential and basic functions in all living organisms, including heart muscle contraction, the release of neurotransmitters in the brain, mammalian cell survival and the migration of cells of the immune system. Two new members of this family (called IP7 and IP8) have the exceptionally unusual property of containing high energy Pyro-phosphate bonds. This is similar to the high energy phosphate bond found in ATP, the main energy storage molecule found in all cells. Like ATP, IP7 and IP8 are also found in all cells analyzed so far, ranging from fungi to humans, but very little is known about their physiological functions. The release of energy from their high energy bonds could, potentially, drive a variety of fundamental biochemical processes and the goal of my research is to identify the physiological role of this novel and exciting class of high-energy molecules.

我的研究主要集中在肌醇磷酸的研究上，肌醇磷酸是一个大家族的小分子，调节所有生物体中的许多基本功能，包括心肌收缩，大脑中神经递质的释放，哺乳动物细胞的存活和免疫系统细胞的迁移。这个家族的两个新成员（称为IP7和IP8）具有包含高能焦磷酸键的异常不寻常的性质。这类似于在ATP中发现的高能磷酸键，ATP是所有细胞中发现的主要能量储存分子。与ATP一样，IP7和IP8也存在于从真菌到人类的所有细胞中，但对它们的生理功能知之甚少。从它们的高能键释放能量可能会驱动各种基本的生化过程，我研究的目标是确定这种新颖而令人兴奋的高能分子的生理作用。

项目成果

The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes.

• DOI: 10.1111/mmi.13766
• 发表时间: 2017-10
• 期刊: Molecular microbiology
• 影响因子: 3.6
• 作者: Cordeiro CD;Saiardi A;Docampo R
• 通讯作者: Docampo R

Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome

• DOI: 10.1021/acschembio.8b00357
• 发表时间: 2018-08-01
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: Azevedo, Cristina;Singh, Jyoti;Saiardi, Adolfo
• 通讯作者: Saiardi, Adolfo