STATISTICAL METHODS IN HUMAN DEVELOPMENT/CLINICAL STUDIES

该项目寻求开发针对问题的新的统计方法 并将现有的方法应用于 以新奇的方式解决问题。继续在两个领域开展工作：(1)统计 人类人口出生体重分布的模拟，以及 (2)生殖发育轨迹的统计建模 儿童青春期的荷尔蒙。 开发一个令人满意的分布统计模型 一个种群的出生体重将有助于更好地理解 出生体重与婴儿死亡率的关系。我们已经开发出 一种模型和一种用于将模型与数据进行拟合的方法 测量选定的出生体重分布特征。我们现在是 将我们的技术应用于美国出生体重和围产儿死亡率数据 为了评估死亡率预测的准确性，可以使用以下特征 我们的技术测量的出生体重分布。 儿童血清促性腺激素和性腺激素水平的变化 发育到青春期。我们已经对……进行了简明的描述 通过对某些非线性函数的拟合研究青春期激素发育 激素水平的对数随时间变化的回归模型 无论是睾丸体积还是晒黑期。我们目前正在比较 男童FSH、LH和抑制素的发育轨迹 女孩们。

This project seeks to develop new statistical methodologies for problems in human development and to apply existing methodologies to those problems in novel ways. Work continues in two areas: (1) statistical modeling of the distribution of birthweights in human populations, and (2) statistical modeling of developmental trajectories of reproductive hormones in children through puberty. Development of a satisfactory statistical model for the distribution of birthweights in a population iwll facilitate a refined understanding of the relationship of birthweight to infant mortality. We have developed a model and a method for fitting the model to data that allow us to measure selected features of birthweight distributions. We are now applying our techniques to U.S. birthweight and perinatal mortality data to assess how well mortality rates arfe predicted by features of birthweight distributions that our technique measures. Serum levels of gonadotropins and gonadal hormones change as children develop through puberty. We have develope parsimonious descriptions of hormonal development through puberty by fitting certain nonlinear regression models to hte logarithm of hormone level as a function of either testis volume or Tanner stage. We are currently comparing developmental trajectories of FSH, LH, and inhibin between boys and girls.