PATERNALLY-MEDIATED EFFECTS ON REPRODUCTION

从历史上看，影响遗传和环境因素的研究 后代的繁殖和随后的发展一直是 以雌性为中心。经过对世界长达一年的评估 然而，文献表明，有必要对男性媒介的疟疾进行流行病学研究 生育结果是明确的。因此，我们已从 欧洲正在进行怀孕和儿童时期的纵向研究 在英国布里斯托尔(“ALSPAC”)。在ALSPAC的研究中，超过7000人 在埃文县接生的妇女的伴侣， 英国在1991-2年间提供了终生职业和毒物接触 历史。婴儿和他们的父母将被跟踪七年 好几年了。我们对母亲和父亲的职业历史进行了编码， 使用英国标准职业代码，并将自我分类 报告了在工作和家里暴露的情况。 四项研究正在进行中。首先是对 父亲职业和/或自我报告的暴露与 胎儿发育。法罗博士正在使用母体数据进行同样的研究。 父亲和母亲对他职业的报告的一致性 正在第三项研究中进行研究。最后，我们完成了一项研究 关于辐射到性腺用于医疗目的；有一个提示性的 但胎儿生长发育未见明显下降。

Historically, research on genetic and environmental factors affecting reproduction and subsequent development of the offspring has been centered on the female. After a year-long assessment of the world literature, however, the need for an epidemiologic study of male-mediated reproductive outcomes was clear. Therefore we have obtained data from the European Longitudinal Study of Pregnancy and Childhood being conducted at Bristol, England ("ALSPAC"). In the ALSPAC study, more than 7,000 partners of women who delivered infants in Avon County, England during 1991-2 provided lifetime occupational and toxic exposure histories. The infants and their parents will be followed for seven years. We have coded occupational histories of both mothers and father, using the British Standard Occupational Codes, and categorized the self- reported exposures on the job and in the home. Four studies are in progress. First is the investigation of the association of paternal occupation and/or self-reported exposure with fetal growth. Dr. Farrow is doing the same study using maternal data. The concordance between father's and mother's report of his occupation is being examined in the third study. Finally, we have completed a study on radiation to the gonads for medical purposes; there was a suggestive but non-significant decrease in fetal growth.