Determining the mechanisms of tolerance after autologous stem cell transplantation for Multiple Sclerosis – the role of CD39+ T regulatory cells

确定多发性硬化症自体干细胞移植后的耐受机制 — CD39 T 调节细胞的作用

• 批准号: nhmrc : 1132822
• 金额: $ 5.88万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-mechanisms-tolerance-regulatory-cells/948712
• 关键词: Determining; mechanisms; tolerance; after; autologous

Autologous haematopoietic stem cell transplant offers relief for patients with aggressive forms of autoimmune diseases such as multiple sclerosis. Here, we aim to understand how this therapy relieves symptoms in multiple sclerosis patients by studying the biology of CD39+ T regulatory cells. Understanding these immune-suppressing cells can lead to the development of new transplant procedures without chemotherapy and ultimately improve transplant outcomes for autoimmune disease patients.

自体造血干细胞移植为患有侵袭性自身免疫性疾病（如多发性硬化症）的患者提供了缓解。在这里，我们的目标是了解这种疗法如何缓解症状的多发性硬化症患者通过研究CD39+ T调节细胞的生物学。了解这些免疫抑制细胞可以导致新的移植程序的发展，而无需化疗，并最终改善自身免疫性疾病患者的移植结果。