权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

SELENIUM METABOLISM AND ANTICARCINOGENIC ACTION

硒的代谢和抗癌作用

基本信息

批准号：
5207411
负责人：
HOWARD GANTHER
金额：
--
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

项目摘要

The identification of novel selenium compounds that have good chemopreventive activity and low toxicity is of great potential benefit. We have uncovered important determinants of these effects that resulted in the discovery of a new class of chemopreventive compounds. These compounds provide a means for relatively straightforward exploration of mechanisms of chemopreventive action compared to other organoselenium compounds that show less metabolic stability. It is proposed that lipophilic derivatives of selenium and sulfur are produced through known biochemical reactions to create similar types of chemopreventive compounds. The purpose of this study is to synthesize novel organoselenium compounds for testing, study their metabolism in the whole animal to correlate critical metabolites with chemopreventive activity, and define the biochemical origin of critical metabolites in cell-free systems. The long-term goal is to develop improved chemopreventive compounds of low toxicity for possible long-term use in humans. This work will lead to a better understanding of chemopreventive mechanisms of selenium. It also provides an important conceptual advance in understanding how chemopreventive activity can be developed and enhanced during the metabolism of selenium or sulfur in plants and animals.

新型富硒化合物的鉴定具有化学预防活性和低毒性，具有很大的潜在效益。我们发现了这些影响的重要决定因素，这些因素导致了一类新的化学预防化合物的发现。这些化合物为相对直接的探索提供了一种方法化学预防作用机制与其他有机硒的比较代谢稳定性较差的化合物。现建议：硒和硫的亲脂衍生物是通过已知的生化反应产生类似类型的化学预防化合物。这项研究的目的是综合小说有机硒化合物的检测，研究它们在整体上的代谢动物将关键代谢物与化学预防活性相关联，并确定了关键代谢物的生化来源系统。长期目标是开发改进的化学预防措施。可能在人体上长期使用的低毒化合物。这部作品将有助于更好地理解化学预防的机制。硒。它还在概念上提供了一个重要的进步了解如何发展和加强化学预防活动在动植物体内硒或硫的代谢过程中。