Developing diagnostics and therapeutics for preeclampsia: targeting a novel placental specific sFlt-1 variant

先兆子痫是一种可怕的妊娠疾病，在全球范围内造成数千名母亲和婴儿死亡。它是由一种叫做sFlt-1的蛋白质从胎盘中泄漏出来并攻击母亲的器官引起的。最近，一种新的sflt-1亚型被发现是胎盘特异性的。它可能是子痫前期引起毒素的关键疾病。我们将针对这种胎盘特异性的sFlt-1产生诊断来预测子痫前期，并探索阻断sFlt-1毒性作用的新方法作为开发药物的策略。

Preeclampsia is a dreaded disease of pregnancy, globally responsible for thousands of deaths of mothers and babies. It is caused by a protein called sFlt-1 leaking out of the placenta and attacking the mothers organs. Recently, a new sflt-1 subtype was discovered that is specific to the placenta. It may be the key disease causing toxin in preeclampsia. We will target this placental specific sFlt-1 to generate diagnostics to predict preeclampsia, and explore novel ways to block the toxic effects of sFlt-1 as a strategy to develop drugs.