ETHNICITY AND VASCULAR REACTIVITY

种族和血管反应性

• 批准号: 5219436
• 负责人: C M STEIN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5219436
• 关键词: African American; caucasian American; clinical research; human subject; hypertension; racial /ethnic difference; sympathetic nervous system; vascular smooth muscle nervous control

Hypertension is a major problem in African-Americans but the contributing factors are poorly understood. This research proposal will compare vascular response and sympathetic regulation in African-Americans and Caucasians to allow examination of both factors and their interaction. These studies will attempt to physiologically localize the site of the attenuated response to isoproterenol in African-Americans that we have demonstrated and focus future molecular biology, mechanism-based techniques on these potential target sites. An understanding of the regulation of sympathetic activity by diurnal rhythm and stress will provide information about the role of these two mechanisms in the pathogenesis of hypertension and allow characterization of a prehypertensive state during which pharmacological intervention could arrest or retard the process.

高血压是非洲裔美国人的主要问题， 因素知之甚少。 这项研究计划将比较 非裔美国人的血管反应和交感神经调节， 高加索人允许检查这两个因素及其相互作用。 这些研究将试图在生理上定位的网站， 在非裔美国人中， 展示和关注未来的分子生物学， 在这些潜在的目标网站上的技术。 的理解 昼夜节律和压力对交感神经活动的调节将 提供资料，说明这两个机制在 高血压的发病机制，并允许表征 高血压前期状态，在此期间，药物干预可以 阻止或延缓这一进程。