ETHNICITY AND VASCULAR REACTIVITY

高血压是非裔美国人的一个主要问题，但 人们对这些因素知之甚少。这项研究提案将比较 非裔美国人和美国人的血管反应和交感神经调节 高加索人允许检查这两个因素及其相互作用。 这些研究将试图从生理上定位 非裔美国人对异丙肾上腺素的反应减弱 展示并关注未来的分子生物学，以机理为基础 关于这些潜在目标地点的技术。对这一概念的理解 昼夜节律和应激意志对交感神经活动的调节 提供有关这两个机制在 高血压的发病机制并允许表征一种 高血压前期状态，在此期间药物干预可以 逮捕或拖延这一进程。

Hypertension is a major problem in African-Americans but the contributing factors are poorly understood. This research proposal will compare vascular response and sympathetic regulation in African-Americans and Caucasians to allow examination of both factors and their interaction. These studies will attempt to physiologically localize the site of the attenuated response to isoproterenol in African-Americans that we have demonstrated and focus future molecular biology, mechanism-based techniques on these potential target sites. An understanding of the regulation of sympathetic activity by diurnal rhythm and stress will provide information about the role of these two mechanisms in the pathogenesis of hypertension and allow characterization of a prehypertensive state during which pharmacological intervention could arrest or retard the process.