ALLOPURINOL AND THE PREVENTION OF DEATH, TISSUE INJURY, AND SEIZURES IN CHD

这是一项随机、双盲的临床试验。 别嘌醇对发育脑损伤的神经保护作用 对缺氧缺血的侮辱。接受心脏手术的婴儿 需要循环骤停的患者使用别嘌醇或 手术前服用安慰剂。主要结果衡量标准是尖锐的。 脑病(包括昏迷和癫痫)和死亡。婴儿经历了 随访中的神经学检查和发育评估 年龄不超过两岁。长期以来，人们就知道缺氧缺血是 这是细胞死亡和组织坏死的重要原因。确切的生物化学 受伤原因仍在紧张调查中。其中最 在这一系列研究中令人着迷的发现是反常的氧气 新陈代谢在组织损伤中起着重要作用。有越来越多的 证据表明氧自由基的形成是一种 重要的生化级联作用于最终的生产 对细胞的侮辱。这种模式提供了一种潜在的治疗方法 可能预防或改善的干预机制 缺氧再灌注损伤的后果。别嘌醇可能会阻止 缺血后组织中自由基的形成。截至目前251 患者已经参加了临床试验。中期统计数据 计划在1996年春季对主要成果进行分析。

This is a randomized, double blind treatment trial of the putative neuroprotective effects of allopurinol on the developing brain exposed to hypoxic-ischemic insults. Infants undergoing cardiac surgery which requires circulatory arrest are treated with either allopurinol or a placebo prior to surgery. The major outcome measures are acute encephalopathy, (including coma and seizures), and death. Infants undergo neurological examination and developmental assessment in follow-up visits up to two years of age. It has long been known that hypoxic-ischemia is a potent cause of cell death and tissue necrosis. The exact biochemistry of injury is still under intense investigation. One of the most fascinating discoveries in this line of research is that aberrant oxygen metabolism plays a role in tissue injury. There is a growing body of evidence which has identified oxygen free radical formation as an important biochemical cascade operative in the ultimate production of cellular insult. This model serves to provide a potential therapeutic mechanism of intervention that might prevent or ameliorate the consequences of hypoxia reperfusion injury. Allopurinol may prevent the formation of free radicals in post ischemic tissues. To date 251 patients have been enrolled in the clinical trial. An interim statistical analysis of primary outcomes is planned for spring 1996.