METABOLIC RATE AND PROTEIN, CARBOHYDRATE AND LIPID METABOLISM IN OBESITY

本研究的目的是：a）确定胰岛素的作用机制 肥胖受试者的抵抗力。 对六名健康女性的核磁共振研究表明， 由于葡萄糖缺乏而导致的肌肉糖原合成的改善 转运/磷酸化，其随着体重减轻而部分逆转; B）评估非裔美国人中的差异胰岛素抵抗， 白人肥胖女性 到目前为止，已有14名非洲裔美国妇女被 研究了 初步数据表明，胰岛素 抑制游离脂肪酸和葡萄糖摄取的敏感性 肥胖的非裔美国女性 蛋白质周转的数据和 正在分析抗脂肪分解作用。 目前，白人女性 被研究。

The aim of the study is: a) to determine the mechanism of insulin resistance in obese subjects. NMR studies in six healthy women showed an improvement of muscle glycogen synthesis due to a defect in glucose transport/phosphorylation which was partly reversed with weight loss; b) to evaluate differential insulin resistance in African-American and Caucasian obese women. To date fourteen African-American women have been studied. Preliminary data suggests substantial differences in insulin sensitivity for suppression of free fatty acids and glucose uptake in obese African-American women. The data for protein turnover and antilipolysis are being analyzed. At present time, Caucasian women are being studied.