MICA: Targeting C5aR in chronic inflammation, renal fibrosis and late graft dysfunction

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Early inflammation after organ transplantation caused by disturbance of blood flow can cause tissue damage and increase the risk of graft dysfunction. Complement is a set of inflammatory proteins that are easily activated during organ transplantation and we have shown it may have a causal role in this type of injury. Our aim is to identify whether the tissue receptor that detects the activated complement fragment known as C5a can be blocked to protect kidneys during transplantation. If this can be achieved with a new agent that we are testing in mice, this could lengthen the life of the transplant and make more kidneys available by organ donation.