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R-ACTIVATED PROTEIN C (APC) DOSE RANGING STUDY IN HEREDITARY PROTEIN C DEFICIENCY

R-ACTIVATED PROTEIN C (APC) DOSE RANGING STUDY IN HEREDITARY PROTEIN C DEFICIENCY
R 激活蛋白 C (APC) 治疗遗传性蛋白 C 缺乏症的剂量范围研究
批准号：
5222210
负责人：
KENNETH BAUER
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5222210
关键词：
blood /lymphatic pharmacology blood coagulation disorders clinical research clinical trial phase I congenital blood protein disorder dosage drug screening /evaluation enzyme activity fibrinolytic agents human subject pharmacokinetics protein C

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中文摘要
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英文摘要
This study will determine the intravenous infusion rate of r-activated protein C and plasma concentration of APC that reduces markers of activated coagulation in patients with hereditary protein C deficiency. The study will determine the pharmacokinetics of rAPC in hereditary protein C deficient patients and determine the safety of 24-hour rAPC infusions.
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R-ACTIVATED PROTEIN C (APC) DOSE RANGING STUDY IN HEREDITARY PROTEIN C DEFICIENCY