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Role of iNKT cells and the lymphoid structures within visceral adipose tissue in the control of inflammation and obesity

iNKT 细胞和内脏脂肪组织内的淋巴结构在控制炎症和肥胖中的作用

基本信息

批准号：
MR/M011542/1
负责人：
Cecile Benezech
金额：
$ 88.87万
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FM011542%2F1
关键词：
Role iNKT cells lymphoid structures

项目摘要

Obesity has become a major health issue in most industrialised countries. It predisposes to cardiovascular disease and is associated with premature mortality. Chronic inflammation in adipose tissue is important in obesity, but use of anti-inflammatory therapies has had very modest or no efficacy in restoring metabolic health. Recent studies showed that stimulations of certain populations of immune cells in adipose tissue could improve inflammation, induce weight loss and ameliorate type 2 diabetes. But the precise mechanisms involved remain unknown. One fat depot, the omentum, is particularly rich in immune clusters where inflammatory cells are concentrating during infection and peritonitis (inflammation of the peritoneal cavity). In this project, we want to understand the role of the omentum in the regulation of inflammation and the development of obesity. In particular we wish to elucidate whether this organ is responsible for the beneficial effect of immune-intervention in obesity. We will use a mouse model of peritonitis to study the role of the omentum in inflammation. This work will enhance our knowledge concerning the mechanisms underlying inflammation and the defense of the peritoneal cavity against infections and open new roads for the development of therapeutics tools in the treatment of inflammation in obesity. Using a mouse model of obesity we will examine the role of the omentum in the development of obesity and its treatment by immune-intervention. This work will pave the way to future translational studies looking at the omentum in humans and the therapeutic benefit of their targeting in inflammatory settings (such as appendicitis and pancreatitis) and in obesity.

肥胖已成为大多数工业化国家的主要健康问题。它易患心血管疾病，并与过早死亡有关。脂肪组织中的慢性炎症在肥胖症中是重要的，但是使用抗炎疗法在恢复代谢健康方面具有非常有限的功效或没有功效。最近的研究表明，刺激脂肪组织中的某些免疫细胞群体可以改善炎症，诱导体重减轻并改善2型糖尿病。但涉及的确切机制仍不清楚。一种脂肪储存库，网膜，特别富含免疫簇，其中炎性细胞在感染和腹膜炎（腹膜腔的炎症）期间集中。在这个项目中，我们想了解网膜在炎症调节和肥胖发展中的作用。特别是，我们希望阐明该器官是否负责免疫干预对肥胖的有益作用。我们将使用腹膜炎的小鼠模型来研究网膜在炎症中的作用。这项工作将提高我们对炎症机制和腹膜腔防御感染的认识，并为肥胖炎症治疗工具的开发开辟新建道路。使用肥胖小鼠模型，我们将研究网膜在肥胖发展中的作用及其免疫干预治疗。这项工作将为未来的转化研究铺平道路，这些研究着眼于人类网膜及其在炎症环境（如阑尾炎和胰腺炎）和肥胖症中的治疗益处。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.

DOI：
10.1038/ncomms12651
发表时间：
2016-09-01
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Jackson-Jones, Lucy H.;Duncan, Sheelagh M.;Magalhaes, Marlene S.;Campbell, Sharon M.;Maizels, Rick M.;McSorley, Henry J.;Allen, Judith E.;Benezech, Cecile
通讯作者：
Benezech, Cecile

Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum

中性粒细胞介导大网膜脂肪相关淋巴簇捕获腹膜污染物

DOI：
10.1101/774968
发表时间：
2019
期刊：
影响因子：
0
作者：
Jackson-Jones L
通讯作者：
Jackson-Jones L

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome.

DOI：
10.1161/hypertensionaha.117.09242
发表时间：
2017-07-24
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
0
作者：
Coan PM;Barrier M;Alfazema N;Carter RN;Marion de Procé S;Dopico XC;Garcia Diaz A;Thomson A;Jackson-Jones LH;Moyon B;Webster Z;Ross D;Moss J;Arends MJ;Morton NM;Aitman TJ
通讯作者：
Aitman TJ

Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL.

DOI：
10.1371/journal.pone.0151848
发表时间：
2016
期刊：
PloS one
影响因子：
3.7
作者：
Cordeiro OG;Chypre M;Brouard N;Rauber S;Alloush F;Romera-Hernandez M;Bénézech C;Li Z;Eckly A;Coles MC;Rot A;Yagita H;Léon C;Ludewig B;Cupedo T;Lanza F;Mueller CG
通讯作者：
Mueller CG

Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation.