Developing mouse models of diffuse large B cell lymphoma for therapeutic discovery

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Diffuse large B cell lymphomas are aggressive cancers of white blood cells. Gene mutations play significant yet poorly understood roles in the cause of these lymphomas and their resistance to drug treatments. I plan to develop new mouse models of lymphoma to identify factors that cause lymphoma to develop in living organisms and factors that cause them to resist drug treatment. I will also test if combinations of multiple drugs can effectively and safely treat these lymphomas.