EFFECT OF SDB ON SYMPATHETIC VASOMOTOR OUTPUT AND REGULATION OF DAYTIME BP

SDB对交感血管舒缩输出的影响和日间血压的调节

• 批准号: 5224581
• 负责人: JAMES B SKATRUD
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5224581
• 关键词: blood pressure; chemoreceptors; clinical research; human subject; hypertension; neurogenic hypertension; respiratory airflow disorder; sleep apnea; sleep disorders; vascular smooth muscle nervous control; vasoconstriction

Our overall goal is to determine the mechanism whereby sleep disordered breathing (SDB) (apnea/hyponea and high upper airway resistance) causes sustained daytime hypertension. Our specific aim is to determine if hypertensive subjects with SDB have a sensitized chemoreflex regulation of sympathetic outflow and augmented neurogenic vasoconstriction.

我们的总体目标是确定睡眠障碍的机制， 呼吸（SDB）（呼吸暂停/低通气和高上气道阻力）导致 持续的日间高血压 我们的具体目标是确定 SDB高血压受试者具有敏化的化学反射调节 交感神经流出和神经性血管收缩增强。