GENERAL CLINICAL RESEARCH CENTER

全科临床研究中心

• 批准号: 2283025
• 负责人: JOHN G CLARKSON
• 金额: $ 27.67万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2283025
• 关键词: clinical research; human subject

This is a competitive renewal application for the continued support of a General Clinical Research Center (GCRC) at the University of Miami (UM)/Jackson Memorial (JM) Center. The primary function of the GCRC will be to continue to: 1) Promote and enhance high quality productive clinical investigation. 2) Develop a strong clinical investigation training program at all levels including medical students, housestaff, fellows and junior faculty. 3) Facilitate cross fertilization and interaction between basic scientists and clinical faculty. The physical facility consists of an eight-bed inpatient unit, and outpatient component with three examination rooms and a procedure room, a sample processing and storage laboratory, a metabolic kitchen, nurses station, conference room, computer room, and administrative offices. The center is strategically located in proximity to the main stream of clinical activities including ward medicine and surgery, intensive care units, coronary care unit, radiology, pathology and other ancillary facilities. The center is jointly operated by the UM and JMH based both on mutual academic and fiscal commitments and responsibilities. The UM/JM Medical Center is one of the largest in the nation and has a catchment area population of over two million. Use of the GCRC is open to all investigators in the medical center including basic scientists. This proposal contains 26 protocols covering multiple disciplines including Pediatrics/Neonatology, Surgery, Medicine/Diabetes, Oncology, Hematology, Hepatology, AIDS, Psychiatry, Psycholoyy, Neurology, Dermatology, Immunology, Epidemiology/Nutrition, Ophthalmology, Obstetrics and Gynecology. In addition, basic scientists are principal investigators on ten of the protocols. Some of the history and recent development at the UM/JM Medical Center relevant to this application are briefly reviewed with emphasis on: 1. Rapid physical and academic growth. 2. Increase in quantity and quality of biomedical research. 3. Increasing collaborative interaction between basic scientists and the clinical faculty. Finally, the increasing need for the GCRC at this medical center is reflected in doubling of the number of protocols in this application compared to the initial one four years ago.

这是一份竞争性续订申请，旨在继续支持 迈阿密大学综合临床研究中心(GCRC) (嗯)/杰克逊纪念(JM)中心。政府资源中心的主要职能是 继续：1)促进和提升高质量生产力 临床调查。2)开展强有力的临床研究 各级培训计划，包括医学生、家政人员、 研究员和初级教员。3)促进异种受精和 基础科学家和临床教师之间的互动。 实体设施包括一个有八张床位的住院病房，以及 门诊部分，有三个检查室和一个程序室， 样品处理和储存实验室、新陈代谢厨房、护士 车站、会议室、电脑室和行政办公室。这个 中心地处战略位置，靠近 临床活动包括病房内科和外科、重症监护 科室、冠心病护理病房、放射科、病理学及其他辅助单位 设施。该中心由UM和JMH联合运营，总部设在两者 关于相互的学术和财政承诺和责任。这个 UM/JM医疗中心是全国最大的医疗中心之一，拥有 集水区人口超过200万。 GCRC的使用对医学中心的所有研究人员开放 包括基础科学家。该提案包含26项议定书，涵盖 多个学科，包括儿科/新生儿科、外科、 医学/糖尿病、肿瘤学、血液学、肝脏病学、艾滋病、精神病学 心理学、神经学、皮肤病学、免疫学、流行病学/营养学、 眼科学、产科和妇科学。此外，基础科学家 是其中十个方案的首席调查员。一些历史 以及UM/JM医疗中心与此相关的最新发展 对其应用作了简要回顾，重点是：1.快速物理和 学业上的成长。(二)提高生物医药的数量和质量。 研究。3.加强基础设施之间的协同互动 科学家和临床教员。最后，日益增长的对 这个医疗中心的GCRC反映在人数翻了一番 与最初的四年相比，此应用程序中的协议 那是以前的事了。

项目成果

m-Hydroxybenzoylecgonine: an important contributor to the immunoreactivity in assays for benzoylecgonine in meconium.

间羟基苯甲酰爱康宁：胎粪中苯甲酰爱康宁测定中免疫反应性的重要贡献者。

• DOI: 10.1093/jat/17.6.348
• 发表时间: 1993
• 期刊: Journal of analytical toxicology
• 影响因子: 2.5
• 作者: Steele,BW;Bandstra,ES;Wu,NC;Hime,GW;Hearn,WL
• 通讯作者: Hearn,WL

Rabbit cingulate cortex: cytoarchitecture, physiological border with visual cortex, and afferent cortical connections of visual, motor, postsubicular, and intracingulate origin.

兔扣带皮层：细胞结构、与视觉皮层的生理边界以及视觉、运动、皮下后和扣带内起源的传入皮层连接。

• DOI: 10.1002/cne.902480106
• 发表时间: 1986
• 期刊: The Journal of comparative neurology
• 作者: Vogt,BA;Sikes,RW;Swadlow,HA;Weyand,TG
• 通讯作者: Weyand,TG

The effects of corticosteroids on lymphocyte recirculation in humans: analysis of the mechanism of impaired lymphocyte migration to lymph node following methylprednisolone administration.

皮质类固醇对人体淋巴细胞再循环的影响：甲基强的松龙给药后淋巴细胞迁移至淋巴结受损的机制分析。

• 发表时间: 1995
• 期刊: Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
• 作者: Sackstein,R;Borenstein,M
• 通讯作者: Borenstein,M

Intraportal islet allografts in type I diabetes mellitus.

I 型糖尿病的门静脉内胰岛同种异体移植。

• 发表时间: 1992
• 期刊: Transplantation proceedings
• 影响因子: 0.9
• 作者: Alejandro,R;Burke,G;Shapiro,ET;Strasser,S;Nery,J;Ricordi,C;Esquenazi,V;Miller,J;Mintz,DH
• 通讯作者: Mintz,DH

Effects of methylprednisolone administration on lymphocyte LECAM-1, CD44, and LFA-1 expression. Implications for steroid-induced lymphopenia.

甲基泼尼松龙给药对淋巴细胞 LECAM-1、CD44 和 LFA-1 表达的影响。

• DOI: 10.1111/j.1749-6632.1993.tb17183.x
• 发表时间: 1993
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Sackstein,R