HELICOBACTER PYLORI AND N-NITROSO COMPOUNDS

本项目的目标是确定氨是否 产生的幽门螺杆菌尿素酶有助于形成 硝酸盐和N-亚硝基化合物。 共有20名患者感染了 本研究将招募幽门螺杆菌。 研究受试者将 在接受抗H之前和之后给予口服剂量的N-尿素。幽门 三联疗法N-硝酸盐和N-亚硝基脯氨酸的浓度 在每次24小时尿液样本中测量。 显著 假设这些化合物的尿浓度降低 感染清除后。

The objective of this project is to determine whether or not ammonia generated by Helicobacter pylori urease contributes to the formation of nitrate and N-nitroso compounds. A total of 20 patients infected with Helicobacter pylori will be recruited for the study. Study subjects will be given an oral dose of N-urea before and after receiving anti-H. pylori triple therapy. The concentration of N-nitrate and N-nitrosoproline will be measured in a 24 hour urine specimen on each occasion. A significant decrease of the urinary concentration of these compounds is hypothesized after clearance of the infection.