FEEDBACK CONTROL OF GROWTH HORMONE SECRETION

生长激素分泌的反馈控制

• 批准号: 5225410
• 负责人: JOSEPH M GERTNER
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5225410
• 关键词: adolescence (12-20); child (0-11); child physical development; clinical research; hormone binding protein; hormone regulation /control mechanism; human puberty; human subject; insulinlike growth factor; secretion; sex hormones; somatotropin

The Investigators continues to study the relationship between pubertal development and the secretion of and sensitivity to growth hormone. In adolescent boys and girls IGF-1 levels were found to be more dependent on sex hormone levels than on nocturnal growth hormone secretion. This difference was not dependent on puberty-related changes in the IGF binding proteins IGFBP-1, IGFBP-2, or IGFBP-3. This finding was presented at the Annual 1994 meeting of the Endocrine Society and is being prepared for publication.

研究人员继续研究青春期与 生长激素的分泌和敏感性。 在 青春期男孩和女孩的IGF-1水平被发现更依赖于 对性激素水平的影响要大于对夜间生长激素分泌的影响。 这 差异不依赖于青春期相关的IGF变化 结合蛋白IGFBP-1、IGFBP-2或IGFBP-3。 该结果 在1994年内分泌学会年会上提出， 正在准备出版。