EVALUATION OF TREATMENT REGIMENS IN CHILDHOOD ACUTE LYMPHOID LEUKEMIA

儿童急性淋巴细胞白血病治疗方案的评估

• 批准号: 5225441
• 负责人: JACK VAN HOFF
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5225441
• 关键词: acute lymphocytic leukemia; asparaginase; clinical research; combination cancer therapy; cytosine arabinoside; drug administration rate /duration; drug screening /evaluation; human subject; human therapy evaluation; methotrexate; neoplasm /cancer chemotherapy; pediatric neoplasm /cancer

Four different consolidation regimens for childhood ALL are being compared in this phase III POG study. The principle questions are the benefit of asparaginase or Ara-C when added to intermediate dose methotrexate and the efficacy of a shorter more intensive consolidation vs. a "spread out" one for both high and low risk patients (POG #8602).

四种不同的儿童巩固方案都是 在这项第三阶段POG研究中进行了比较。主要问题是 添加到中等剂量的天冬酰胺酶或Ara-C的益处 甲氨蝶呤与更短、更密集巩固的疗效 对高风险患者和低风险患者进行“分散”治疗(POG#8602)。