ULTRAVIOLET A-1 LIGHT THERAPY IN HUMANS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

UVA(320-340 nm)光是一种有效但无害的治疗方法 用于治疗系统性红斑狼疮(SLE)患者。 长期目标是了解UV-A1光是否可以控制 疾病长期，长期使用是否会中毒，以及如何 它的交付可以针对短期和长期试验进行优化。这个 具体目标将是评估短期和长期剂量 水平、所需处理频率、环境影响 治疗过程中的温度，最有利的灯具放置， UV-A光与其他疗法的相互作用及其机制 UVA的行动。这些观察将有助于开发这种疗法，即 史无前例的。

UVA (320-340nm) light is an effective yet innocuous therapeutic modality for the treatment of patients with systemic lupus erythematosus (SLE). The long term objectives are to learn whether UV-A1 light can control disease long term, whether it becomes toxic with prolonged use, and how its delivery can be optimized for both short and long term trials. The specific aims will be to evaluate over the short and long term dose level, required frequency of treatments, the effect of ambient temperature during treatment, the most advantageous lamp placement, the interaction of UV-A light with other therapies and the mechanisms of UVA's action. The observations will serve to develop this therapy, the first of its kind.