Newton001-Developing a partnership to inform UK-Brazil TB control:Investigating BCG vaccination efficacy following latent TB treatment (TBTVacc)

Newton001-建立伙伴关系，为英国和巴西的结核病控制提供信息：研究潜伏性结核病治疗后卡介苗疫苗接种的效果 (TBTVacc)

• 批准号: MR/M02654X/1
• 负责人: Ibrahim Abubakar
• 金额: $ 8.35万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM02654X%2F1
• 关键词: Newton001; Developing; partnership; inform; UK

Tuberculosis (TB) is a major cause of the global disease burden. We plan to investigate whether the human immunity to tuberculosis as a result of BCG vaccination is different after individuals complete treatment for latent TB. This will allow us to test whether BCG can protect individuals following clearance of the tuberculosis bacterium. We would develop a partnership between UK and Brazilian researchers to undertake the following: Review and summarise any published studies of BCG assessing protection after treatment for latent TB. We will use this information and expert views to try and quantify the impact of vaccinating people after TB treatment.We would organise two workshops, one in Brazil and one in the UK that strengthen the existing collaboration between partners. We will use these workshops to develop our pilot study and to plan the grant application for a major trial. We would ensure there are training opportunities in the UK for Brazilian students, and UK students in Brazil.We will undertake a pilot study in Brazil to investigate the feasibility of undertaking a trial over a 6 month period. The pilot study would examine immunological changes after BCG vaccination in 40 people immediately following the completion of treatment for latent TB.

结核病是造成全球疾病负担的主要原因。我们计划调查在完成对潜伏性结核病的治疗后，接种卡介苗是否会导致人类对结核病的免疫力有所不同。这将使我们能够测试卡介苗在清除结核细菌后是否能够保护个体。我们将发展英国和巴西研究人员之间的合作伙伴关系，以开展以下工作：回顾和总结任何发表的关于卡介苗评估治疗后潜在结核病保护的研究。我们将利用这些信息和专家意见，试图量化结核病治疗后为人们接种疫苗的影响。我们将组织两个研讨会，一个在巴西，一个在英国，以加强合作伙伴之间现有的合作。我们将利用这些研讨会来开展我们的试点研究，并为一项重大试验计划赠款申请。我们将确保在英国为巴西学生和在巴西的英国学生提供培训机会。我们将在巴西进行一项试点研究，以调查在6个月内进行试验的可行性。这项初步研究将检查40人在完成潜伏性结核病治疗后立即接种卡介苗后的免疫学变化。

项目成果

The impact of HIV infection on tuberculosis transmission in a country with low tuberculosis incidence: a national retrospective study using molecular epidemiology.

• DOI: 10.1186/s12916-020-01849-7
• 发表时间: 2020-12-14
• 期刊: BMC medicine
• 影响因子: 9.3
• 作者: Winter JR;Smith CJ;Davidson JA;Lalor MK;Delpech V;Abubakar I;Stagg HR
• 通讯作者: Stagg HR