EPIDEMIOLOGY AND OUTCOME OF STDS IN DRUG USERS

吸毒者性传播疾病的流行病学和结果

• 批准号: 2897970
• 负责人: Carl J Fichtenbaum
• 金额: $ 6.27万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-05 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2897970
• 关键词: HIV infections; behavioral /social science research tag; clinical research; comorbidity; disease /disorder proneness /risk; drug abuse; drug abuse information system; epidemiology; health care cost /financing; health care professional practice; health care service evaluation; health care service utilization; human subject; interview; longitudinal human study; substance abuse epidemiology; syphilis; syphilis test; urban area

DESCRIPTION: (Applicant's Abstract) As we enter the 21 st century, the United States is faced with a problem that has plagued the world for thousands of years. Syphilis remains an important public health problem nearly fifty years after the introduction of penicillin. The proposed new study, called The Epidemiology and Outcome of Syphilis in Drug Users, will be conducted in the urban heartland of America in a city that has been experiencing a syphilis epidemic since 1991. The investigators will study the relationship between drug use and syphilis by evaluating syphilis serology and interview data from 2,200 drug users involved in three separate NIDA- sponsored longitudinal projects to accomplish the following aims: The Epidemiologic Aims include: a) determining the critical risk factors for syphilis and describing the proportion of drug users who develop syphilis; b) evaluating whether drug users in treatment are less likely to develop syphilis; c) evaluating the validity of self-reported information on syphilis compared to serologic testing; d) evaluating whether a syphilis epidemic increases the proportion of drug users who develop HIV infection in an area of low prevalence of HIV infection among drug users. The Health Services/Outcome Aims include: a) evaluating the strategies used to treat and control syphilis in drug users; b) providing data on the site of care for the diagnosis and treatment of syphilis and other STDs; c) determining the adequacy of syphilis follow up in drug users; d) describing how access or barriers to medical care affects the management of syphilis in drug users; e) evaluating the knowledge and practice patterns of health care providers most likely to be involved in the treatment of persons with sexually transmitted diseases; f) determining the cost-effectiveness of syphilis control efforts. To accomplish these aims the investigators will: a) utilize the existing analogous data and stored blood specimens from three NIDA-funded studies; b) test the stored specimens for syphilis and combine this with ongoing syphilis testing in one of the "parent" studies; c) obtain information on study participants and syphilis control efforts from the health department; d) conduct a proportionate survey of 100 health providers. Thus, the major goals of this study are to identify the specific factors associated with the development of syphilis in drug users and evaluate the efforts of health care providers and the public health establishment to provide services to treat and control syphilis in an effort to develop more effective interventions to reduce the occurrence of syphilis.

描述：(申请人摘要) 当我们进入21世纪时，美国面临着一个问题 这个问题已经困扰世界几千年了。梅毒仍然是一个 重要的公共卫生问题在引入近50年后 青霉素。这项拟议的新研究名为《流行病学和 将在城市开展吸毒者梅毒结果调查 美国的心脏地带，在一个一直在经历梅毒的城市 自1991年以来一直流行。调查人员将研究这一关系 通过评估梅毒血清学和 对参与三个不同NIDA的2200名吸毒者的采访数据- 赞助纵向项目以实现以下目标： 流行病学目标包括：a)确定关键危险因素 并描述了吸毒者的比例 梅毒；b)评估接受治疗的吸毒者是否不太可能 发展梅毒；c)评估自我报告信息的有效性 梅毒与血清学检测的比较；d)评估 梅毒流行增加了吸毒者感染艾滋病毒的比例 在吸毒者中艾滋病毒感染率较低的地区感染。 保健服务/成果目标包括：a)评估战略 用于治疗和控制吸毒者的梅毒；b)提供关于 梅毒和其他性传播疾病的诊断和治疗护理场所； C)确定吸毒者梅毒随访的充分性；d) 描述获得医疗服务的机会或障碍如何影响管理层 了解吸毒者的梅毒情况；e)评估吸毒者的知识和行为 最有可能参与的医疗保健提供者的模式 性传播疾病患者的治疗；f)确定 梅毒控制工作的成本效益。 为了实现这些目标，调查人员将：a)利用现有的 来自NIDA资助的三项研究的类似数据和储存的血液样本； B)对储存的标本进行梅毒检测，并将其与正在进行的 在其中一项“家长”研究中进行梅毒检测；c)获得关于 研究参与者和梅毒控制从健康的努力 该部；d)对100名保健提供者进行适当的调查。 因此，本研究的主要目标是确定具体的影响因素 与吸毒者梅毒的发展有关，并评估 卫生保健提供者和公共卫生机构的努力 提供梅毒治疗和控制服务，努力发展梅毒 采取更有效的干预措施，减少梅毒的发生。