EPIDEMIOLOGY AND OUTCOME OF STDS IN DRUG USERS

描述：（申请人摘要） 当我们进入21世纪时，美国面临着一个问题 困扰了世界几千年的疾病 Sys仍然是一个 重要的公共卫生问题近50年后，引进 青霉素。 这项名为《流行病学》的新研究提出， 将在城市进行吸毒者的戒毒治疗结果 美国的心脏地带，在一个城市，一直在经历梅毒 自1991年以来，疫情。 调查人员将研究 通过评估梅毒血清学， 来自2,200名吸毒者的访谈数据，这些吸毒者参与了三个独立的NIDA， 赞助纵向项目，以实现以下目标： 流行病学目的包括：a）确定关键风险因素 并描述吸毒者中 梅毒; B）评估接受治疗的吸毒者是否不太可能 发展梅毒; c）评估自我报告信息的有效性 与血清学检测相比的梅毒; d）评估是否 梅毒流行增加了吸毒者感染艾滋病毒的比例 在吸毒者中艾滋病毒感染率较低的地区， 保健服务/成果目标包括： B）提供关于药物使用情况的数据， 诊断和治疗梅毒和其他性病的护理场所; c）确定吸毒者梅毒后续行动的充分性; d） 描述获得医疗服务的机会或障碍如何影响管理 e）评估吸毒者的知识和做法 卫生保健提供者最有可能参与的模式 性传播疾病患者的治疗; f）确定 梅毒控制工作的成本效益。 为了实现这些目标，研究人员将：a）利用现有的 来自NIDA资助的三项研究的类似数据和储存的血液标本; B）测试储存的标本的梅毒和联合收割机这与正在进行的 在其中一项“母”研究中进行梅毒检测; c）获得以下信息： 研究参与者和卫生部门的梅毒控制工作 （d）对100名保健提供者进行比例调查。 因此，本研究的主要目标是确定具体因素 与吸毒者梅毒发病相关，并评估 卫生保健提供者和公共卫生机构努力 提供治疗和控制梅毒的服务， 更有效的干预措施，以减少梅毒的发生。

DESCRIPTION: (Applicant's Abstract) As we enter the 21 st century, the United States is faced with a problem that has plagued the world for thousands of years. Syphilis remains an important public health problem nearly fifty years after the introduction of penicillin. The proposed new study, called The Epidemiology and Outcome of Syphilis in Drug Users, will be conducted in the urban heartland of America in a city that has been experiencing a syphilis epidemic since 1991. The investigators will study the relationship between drug use and syphilis by evaluating syphilis serology and interview data from 2,200 drug users involved in three separate NIDA- sponsored longitudinal projects to accomplish the following aims: The Epidemiologic Aims include: a) determining the critical risk factors for syphilis and describing the proportion of drug users who develop syphilis; b) evaluating whether drug users in treatment are less likely to develop syphilis; c) evaluating the validity of self-reported information on syphilis compared to serologic testing; d) evaluating whether a syphilis epidemic increases the proportion of drug users who develop HIV infection in an area of low prevalence of HIV infection among drug users. The Health Services/Outcome Aims include: a) evaluating the strategies used to treat and control syphilis in drug users; b) providing data on the site of care for the diagnosis and treatment of syphilis and other STDs; c) determining the adequacy of syphilis follow up in drug users; d) describing how access or barriers to medical care affects the management of syphilis in drug users; e) evaluating the knowledge and practice patterns of health care providers most likely to be involved in the treatment of persons with sexually transmitted diseases; f) determining the cost-effectiveness of syphilis control efforts. To accomplish these aims the investigators will: a) utilize the existing analogous data and stored blood specimens from three NIDA-funded studies; b) test the stored specimens for syphilis and combine this with ongoing syphilis testing in one of the "parent" studies; c) obtain information on study participants and syphilis control efforts from the health department; d) conduct a proportionate survey of 100 health providers. Thus, the major goals of this study are to identify the specific factors associated with the development of syphilis in drug users and evaluate the efforts of health care providers and the public health establishment to provide services to treat and control syphilis in an effort to develop more effective interventions to reduce the occurrence of syphilis.