DEPRESSION, DUAL DIAGNOSIS AND ANTIRETROVIRAL ADHERENCE

抑郁症、双重诊断和抗逆转录病毒药物依从性

• 批准号: 6054738
• 负责人: CAROL A BOVA
• 金额: $ 3.62万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-11-16 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6054738
• 关键词: AIDS therapy; HIV infections; antiAIDS agent; behavioral /social science research tag; clinical research; comorbidity; depression; home health care; human subject; human therapy evaluation; nursing care evaluation; substance abuse related disorder; therapy compliance

The long-term objective of this project is to examine the relationship between depression, dual diagnosis and medication adherence in HIV infected individuals. Understanding adherence behaviors in vulnerable populations is essential to maximizing the clinical effectiveness of highly active antiretroviral therapy (HAART) among all HIV seropositive populations. The specific aims of this study are (1) to describe the prevalence of depression and dual diagnosis (depression and substance abuse) in a cohort of 200 HIV infected individuals currently treated with HAART, (2) to describe the relationship between depression, dual diagnosis and antiretroviral adherence, (3) to examine the relationship between depression, dual diagnosis and response to a home-based nursing intervention to improve adherence to HAART. This is a prospective, descriptive study nested in a randomized clinical trial of a home-based nursing intervention to improve adherence to HAART (Williams, A.). Subjects will be 200 HIV infected individuals enrolled in the parent study. Measures of depression (self-report, Beck Depression Inventory, 5-item mental health subscale of the MOS Short Form) and substance abuse (self-report) will be added to the parent study data collection instrument and measured at baseline in face to face interviews. Adherence data (measured by self report, unannounced pill counts and MEMS cap data) will be collected at baseline, monthly for 3 months then every 3 months for 18 months.

该项目的长期目标是研究艾滋病毒感染者抑郁症、双重诊断和药物依从性之间的关系。 了解弱势人群的依从行为对于在所有 HIV 血清阳性人群中最大限度地提高高效抗逆转录病毒治疗 (HAART) 的临床效果至关重要。 本研究的具体目的是 (1) 描述目前正在接受 HAART 治疗的 200 名 HIV 感染者中抑郁症和双重诊断（抑郁症和药物滥用）的患病率，(2) 描述抑郁症、双重诊断和抗逆转录病毒治疗依从性之间的关系，(3) 检查抑郁症、双重诊断和对家庭护理干预的反应之间的关系，以提高对 HAART 的依从性。这是一项前瞻性、描述性研究，涉及一项旨在提高 HAART 依从性的家庭护理干预的随机临床试验 (Williams, A.)。 受试者将是参加家长研究的 200 名 HIV 感染者。 抑郁症的测量（自我报告、贝克抑郁量表、MOS 简表的 5 项心理健康分量表）和药物滥用（自我报告）将添加到家长研究数据收集工具中，并在面对面访谈中进行基线测量。依从性数据（通过自我报告、未公布的药丸计数和 MEMS 上限数据来衡量）将在基线时收集，每月收集一次，持续 3 个月，然后每 3 个月收集一次，持续 18 个月。