IMPLANTABLE PRESSURE, FLOW AND ECG TELEMETRY

植入式压力、流量和心电图遥测

• 批准号: 6015680
• 负责人: PERRY A MILLS
• 金额: $ 13万
• 依托单位: TRANSOMA MEDICAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6015680
• 关键词: biomedical device power system; biomedical equipment development; blood flow measurement; blood pressure; computer data analysis; dogs; electrocardiography; implant; medical implant science; patient monitoring device; telemetry

Implantable telemetry has progressed substantially over the past decade, with innovative devices being developed for monitoring heart rate, blood pressure, and other key functions in laboratory animals. These devices have allowed researchers to make great strides toward more-humane animal testing, reduced animal use, and improved efficiency and research quality. To date, however, one important aspect of cardiovascular monitoring has not been addressed: blood flow. In this project, the feasibility of a complete system for telemetric monitoring of blood pressure, ECG, and blood flow in conscious, freely moving animals larger than about 3 kg will be evaluated. The system will consist of novel, battery-powered implantable devices, receivers to pick up the telemetered signal; and a data-acquisition system to collect, store, and analyze the data. Key to success of this effort is to establish the feasibility of a novel approach to power reduction that, according to pilot evaluations, appears to be capable of reducing current drain by a factor of 15 or more over the best designs currently available. Phase 1 success will lead to a Phase II project designed to produce a prototype system. We believe that further improvements upon the Phase II design will make this technology viable in the much larger human clinical market. PROPOSED COMMERCIAL APPLICATIONS: Successful completion will result in a valuable new tool for biomedical researchers. In addition, the technology developed here has significant potential for human use once performance is improved in later generation designs.

在过去的十年中，植入式遥测技术取得了长足的进步，开发了用于监测实验室动物心率、血压和其他关键功能的创新设备。这些设备使研究人员能够在更人性化的动物试验、减少动物使用、提高效率和研究质量方面取得重大进展。然而，迄今为止，心血管监测的一个重要方面尚未得到解决：血流。在本项目中，将评估一个完整的系统的可行性，遥测监测血压，心电图和血流在清醒的，自由移动的动物大于约3公斤。该系统将包括新颖的电池供电的植入式设备，接收遥测信号的接收器;以及收集，存储和分析数据的数据采集系统。这一努力成功的关键是建立一种新的方法来降低功率的可行性，根据试点评估，似乎能够将电流消耗降低到目前可用的最佳设计的15倍或更多。第一阶段的成功将导致第二阶段的项目，旨在产生一个原型系统。我们相信，对II期设计的进一步改进将使该技术在更大的人类临床市场中可行。建议的商业应用：成功完成将为生物医学研究人员带来一个有价值的新工具。此外，一旦性能在下一代设计中得到改善，这里开发的技术具有巨大的人类使用潜力。