NORADRENERGIC SYSTEM IN DEPRESSION

抑郁症中的去甲肾上腺素能系统

基本信息

  • 批准号:
    2890431
  • 负责人:
  • 金额:
    $ 13.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1991
  • 资助国家:
    美国
  • 起止时间:
    1991-09-30 至 2001-03-31
  • 项目状态:
    已结题

项目摘要

Converging evidence from years of intensive research has implicated that a disorder of brain norepinephrine and/or serotonin occurs in major depression. However, the basic neurobiology of major depression has not yet been elucidated. The goal of this research is test the hypothesis that a distinct constellation of neurochemical/neuroanatomical deficits occurs in the noradrenergic system (in particular, the locus coeruleus) in major depression. Experiments are designed to address the issues of (1) the precise neurochemical and/or neuroanatomical alterations and (2) the specificity of alterations with respect to psychiatric illness. To address the first issue, concentrations of a number of proteins and substances will be measured throughout the locus coeruleus, and in a major limbic projection area (amygdala) in post-mortem brains from subjects with major depression and from psychiatrically normal control subjects. In particular, a number of noradrenergic and non-noradrenergic proteins which are sites of action of antidepressant drugs will be studied, along with proteins of which levels are modulated in the locus coeruleus by antidepressant treatment. Preliminary findings demonstrates that noradrenergic cell number is a major determinant of noradrenergic protein concentration in the locus coeruleus. Furthermore, cell loss in the locus coeruleus is associated with aging, Alzheimer's disease, and Parkinson's disease. Thus, if cell number in locus coeruleus is altered in psychiatric disease, such a change could complicate measurements of noradrenergic proteins in the locus coeruleus or lead to misinterpretation of neurochemical alterations in the locus coeruleus from major depressives. Thus, noradrenergic neuron density and number will be estimated stereologically in all subjects in parallel with neurochemical measurements. To address the issue of specificity, 4 groups of subjects will be studied: 1) no psychiatric diagnosis, age-matched control subjects dying of natural or accidental causes, 2) suicide victims with major depression, 3) non-suicide subjects with major depression, and 4) suicide victims with Axis I diagnoses other than major depression. This research will extend and clarify major findings of research in the first grant period. Elucidation of the biochemical and/or anatomical alterations of locus coeruleus neurons associated with major depression may yield important information for the development of more effective treatments for this devastating disorder.
来自多年深入研究的越来越多的证据表明

项目成果

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GREGORY ALLEN ORDWAY其他文献

GREGORY ALLEN ORDWAY的其他文献

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{{ truncateString('GREGORY ALLEN ORDWAY', 18)}}的其他基金

Quillen College of Medicine Building 119 Renovation
奎伦医学院119号楼改造
  • 批准号:
    7900124
  • 财政年份:
    2010
  • 资助金额:
    $ 13.7万
  • 项目类别:
COBRE: UMMC: ADMINISTRATIVE CORE
COBRE:UMMC:管理核心
  • 批准号:
    7171136
  • 财政年份:
    2005
  • 资助金额:
    $ 13.7万
  • 项目类别:
COBRE: UMMC: ADMINISTRATIVE CORE
COBRE:UMMC:管理核心
  • 批准号:
    6981813
  • 财政年份:
    2004
  • 资助金额:
    $ 13.7万
  • 项目类别:
Center for Research Excellence Psychiatric Neuroscience
精神神经科学卓越研究中心
  • 批准号:
    6571629
  • 财政年份:
    2002
  • 资助金额:
    $ 13.7万
  • 项目类别:
Center for Research Excellence Psychiatric Neuroscience
精神神经科学卓越研究中心
  • 批准号:
    6796888
  • 财政年份:
    2002
  • 资助金额:
    $ 13.7万
  • 项目类别:
Center for Research Excellence Psychiatric Neuroscience
精神神经科学卓越研究中心
  • 批准号:
    6660398
  • 财政年份:
    2002
  • 资助金额:
    $ 13.7万
  • 项目类别:
NORADRENERGIC SYSTEM IN DEPRESSION BIOLOGY
抑郁症生物学中的去甲肾上腺素能系统
  • 批准号:
    6702325
  • 财政年份:
    2001
  • 资助金额:
    $ 13.7万
  • 项目类别:
Limbic Dopaminergic System in Major Depression
重度抑郁症的边缘多巴胺能系统
  • 批准号:
    7117109
  • 财政年份:
    2001
  • 资助金额:
    $ 13.7万
  • 项目类别:
NORADRENERGIC SYSTEM IN DEPRESSION BIOLOGY
抑郁症生物学中的去甲肾上腺素能系统
  • 批准号:
    6637565
  • 财政年份:
    2001
  • 资助金额:
    $ 13.7万
  • 项目类别:
Limbic Dopaminergic System in Major Depression
重度抑郁症的边缘多巴胺能系统
  • 批准号:
    6686792
  • 财政年份:
    2001
  • 资助金额:
    $ 13.7万
  • 项目类别:
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