Developing and testing pro-thrombotic conjugates for brain AVMs

开发和测试脑 AVM 的促血栓结合物

• 批准号: nhmrc : 1085045
• 负责人: Dr David Inglis
• 金额: $ 34.69万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developing-testing-pro-brain-avms/519056
• 关键词: Developing; testing; pro; thrombotic; conjugates

Rupture of brain blood vessel abnormalities causes stroke in children and young adults. In this project, we will test new methods for occluding abnormal vessels. We use radiation first to induce changes in the vessels, and then target those changes to occlude the vessels. Successful treatment requires combining targeting and clot forming agents. In this project we will test combinations of targeting and clotting agents. The most effective combination will be progressed towards clinical trials.

脑血管异常破裂会导致儿童和年轻人中风。在这个项目中，我们将测试闭塞异常血管的新方法。我们首先使用辐射来诱发血管的变化，然后针对这些变化来闭塞血管。成功的治疗需要结合靶向剂和凝块形成剂。在这个项目中，我们将测试靶向剂和凝血剂的组合。最有效的组合将进入临床试验。