Developing and testing pro-thrombotic conjugates for brain AVMs

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Rupture of brain blood vessel abnormalities causes stroke in children and young adults. In this project, we will test new methods for occluding abnormal vessels. We use radiation first to induce changes in the vessels, and then target those changes to occlude the vessels. Successful treatment requires combining targeting and clot forming agents. In this project we will test combinations of targeting and clotting agents. The most effective combination will be progressed towards clinical trials.