SENBIOTAR: Sensiting Pseudomonas aeruginosa biofilms to antibiotics and reducing virulence through novel target inhibition

SENBIOTAR：使铜绿假单胞菌生物膜对抗生素敏感并通过新的靶标抑制降低毒力

• 批准号: MR/N501852/1
• 负责人: Miguel Camara
• 金额: $ 45.73万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN501852%2F1
• 关键词: SENBIOTAR; Sensiting; Pseudomonas; aeruginosa; biofilms

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection.

基于模型的肺部给药药物开发：治疗铜绿假单胞菌肺部感染的新候选药物的药代动力学分析。

• DOI: 10.1016/j.xphs.2018.09.017
• 发表时间: 2019-01
• 期刊: Journal of pharmaceutical sciences
• 影响因子: 3.8
• 作者: Sou T;Kukavica-Ibrulj I;Soukarieh F;Halliday N;Levesque RC;Williams P;Stocks M;Cámara M;Friberg LE;Bergström CAS
• 通讯作者: Bergström CAS

In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa.

• DOI: 10.3390/molecules23020257
• 发表时间: 2018-01-28
• 期刊: Molecules (Basel, Switzerland)
• 作者: Soukarieh F;Vico Oton E;Dubern JF;Gomes J;Halliday N;de Pilar Crespo M;Ramírez-Prada J;Insuasty B;Abonia R;Quiroga J;Heeb S;Williams P;Stocks MJ;Cámara M
• 通讯作者: Cámara M

Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions.

• DOI: 10.1021/acsomega.0c03004
• 发表时间: 2020-10-13
• 期刊: ACS omega
• 影响因子: 4.1
• 作者: Sou T;Soukarieh F;Williams P;Stocks MJ;Cámara M;Bergström CAS
• 通讯作者: Bergström CAS

Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.

• DOI: 10.1016/j.ejmech.2020.112778
• 发表时间: 2020-12-15
• 期刊: European journal of medicinal chemistry
• 影响因子: 6.7
• 作者: Grossman S;Soukarieh F;Richardson W;Liu R;Mashabi A;Emsley J;Williams P;Cámara M;Stocks MJ
• 通讯作者: Stocks MJ

Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones.

• DOI: 10.3389/fmicb.2016.01171
• 发表时间: 2016
• 期刊: Frontiers in microbiology
• 影响因子: 5.2
• 作者: Nguyen AT;Jones JW;Cámara M;Williams P;Kane MA;Oglesby-Sherrouse AG
• 通讯作者: Oglesby-Sherrouse AG