RENOVATION OF SPACE IN VOLKER HALL

沃尔克大厅空间改造

• 批准号: 6039587
• 负责人: ALBERT F LOBUGLIO
• 金额: $ 100万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6039587
• 关键词: biomedical facility; building /facility design /renovation

This proposal requests matching funds to facilitate a part of the renovation of the Volker Hall Research Tower at the University of Alabama at Birmingham (UAB). Volker Hall was completed in 1971, and remains the largest research building at UAB. The School of Medicine has already initiated this renovation, and has completed work on the North half of Level Five. This proposal is to renovate the remaining half of Level Five and all of Level Six. The occupants of the newly renovated space will be members of the Adhesion Receptor Unit of the Cell Adhesion and Matrix Research Center (CAMRC). This Unit is an interdisciplinary research group with eleven investigators from four departments. The long-term objectives of these investigators are to advance the understanding of adhesion receptors in human diseases (polycystic kidney disease, diabetic nephropathy, basal cell carcinoma), developmental processes (muscle, skin), and anti-tumor therapeutics. The space will house a Molecular Interactions Core Facility that will provide a comprehensive facility for fluorescence resonance energy transfer microscopy, microinjection, time-lapse video microscopy, confocal laser scanning microscopy, interference reflection microscopy, high-resolution digital deconvolution, and transmission and scanning electron microscopy. The CAMRC also supports a Hybridoma Core and Transgenic Core for the Adhesion Receptor Unit and the broader array of CAMRC investigators involved in genetics, cancer, immunology, diabetes, and arthritis research. This project will thus provide state-of-the- art facilities to support PHS-funded research in areas emerging as high priorities for new therapeutic strategies and health maintenance.

该提案要求配套资金，以促进在伯明翰（UAB）的亚拉巴马大学沃尔克大厅研究塔的一部分翻新。Volker Hall于1971年完工，至今仍是UAB最大的研究大楼。医学院已经开始了这项翻新工作，并完成了第五层北半部分的工作。这个提议是要整修第五层剩下的一半和第六层的全部。新装修的空间的居住者将是细胞粘附和基质研究中心（CAMRC）粘附受体单位的成员。该股是一个跨学科的研究小组，有来自四个部门的11名调查员。这些研究人员的长期目标是促进对人类疾病（多囊肾病，糖尿病肾病，基底细胞癌），发育过程（肌肉，皮肤）和抗肿瘤治疗中粘附受体的理解。该空间将容纳一个分子相互作用核心设施，该设施将为荧光共振能量转移显微镜，显微注射，延时视频显微镜，共聚焦激光扫描显微镜，干涉反射显微镜，高分辨率数字解卷积以及透射和扫描电子显微镜提供综合设施。CAMRC还支持粘附受体单位的杂交核心和转基因核心，以及参与遗传学，癌症，免疫学，糖尿病和关节炎研究的更广泛的CAMRC研究人员。因此，该项目将提供最先进的设施，以支持公共卫生系统资助的研究领域的新的治疗战略和健康维护的高度优先事项。