RENOVATION OF SPACE IN VOLKER HALL

该提案要求配套资金，以促进阿拉巴马大学伯明翰分校 (UAB) 沃尔克霍尔研究塔的部分翻修工程。沃尔克大楼 (Volker Hall) 于 1971 年竣工，至今仍是阿拉巴马大学最大的研究大楼。医学院已经启动了这项改造工作，并完成了五层北半部的工作。本提案是对第五层的剩余一半和第六层的全部进行翻修。新装修的空间的居住者将是细胞粘附和基质研究中心（CAMRC）粘附受体单元的成员。该单位是一个跨学科研究小组，由来自四个部门的 11 名研究人员组成。这些研究人员的长期目标是增进对人类疾病（多囊肾病、糖尿病肾病、基底细胞癌）、发育过程（肌肉、皮肤）和抗肿瘤治疗中粘附受体的了解。该空间将设有一个分子相互作用核心设施，为荧光共振能量转移显微镜、显微注射、延时视频显微镜、共焦激光扫描显微镜、干涉反射显微镜、高分辨率数字解卷积以及透射和扫描电子显微镜提供综合设施。 CAMRC 还支持粘附受体单元的杂交瘤核心和转基因核心以及涉及遗传学、癌症、免疫学、糖尿病和关节炎研究的更广泛的 CAMRC 研究人员。因此，该项目将提供最先进的设施，以支持 PHS 资助的新治疗策略和健康维护高度优先领域的研究。

This proposal requests matching funds to facilitate a part of the renovation of the Volker Hall Research Tower at the University of Alabama at Birmingham (UAB). Volker Hall was completed in 1971, and remains the largest research building at UAB. The School of Medicine has already initiated this renovation, and has completed work on the North half of Level Five. This proposal is to renovate the remaining half of Level Five and all of Level Six. The occupants of the newly renovated space will be members of the Adhesion Receptor Unit of the Cell Adhesion and Matrix Research Center (CAMRC). This Unit is an interdisciplinary research group with eleven investigators from four departments. The long-term objectives of these investigators are to advance the understanding of adhesion receptors in human diseases (polycystic kidney disease, diabetic nephropathy, basal cell carcinoma), developmental processes (muscle, skin), and anti-tumor therapeutics. The space will house a Molecular Interactions Core Facility that will provide a comprehensive facility for fluorescence resonance energy transfer microscopy, microinjection, time-lapse video microscopy, confocal laser scanning microscopy, interference reflection microscopy, high-resolution digital deconvolution, and transmission and scanning electron microscopy. The CAMRC also supports a Hybridoma Core and Transgenic Core for the Adhesion Receptor Unit and the broader array of CAMRC investigators involved in genetics, cancer, immunology, diabetes, and arthritis research. This project will thus provide state-of-the- art facilities to support PHS-funded research in areas emerging as high priorities for new therapeutic strategies and health maintenance.