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EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION PROJECTS

校外研究设施建设项目

基本信息

批准号：
6039614
负责人：
NO-HEE PARK
金额：
$ 100万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-30 至 2002-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6039614
关键词：
biomedical facility building /facility design /renovation

项目摘要

The UCLA School of Dentistry requests funds for the development of the Jane and Jerry Weintraub Center for Reconstructive Biotechnology (WCRB), with the express purpose of addressing the substantial challenges of restoring the craniofacial complex facing both patients and health professionals. Specifically, we are requesting matching funds for the conversion of 5,386 gross square feet of newly-acquired space in the UCLA Center for Health Sciences into a research complex that houses the WCRB in one central facility. The WCRB has been formed out of recognition that defects in the head and neck secondary to tumor ablation, injury, or congenital malformation can result in severe functional impairment and facial disfigurement. The WCRB's primary research objective, i.e., restoration of the craniofacial complex, involves the study of cellular and molecular biology of wound healing, tissue remodeling and regeneration, biomaterials and bioengineering, a range of translational research, and clinical outcome studies. The existing programs at UCLA in implant and maxillofacial prosthodontics, plastic and reconstructive surgery, head and neck surgery, orthopedic surgery, radiation oncology and dermatology are the strength for our unique capabilities and offer outstanding potential for rapid continued growth. Building on the clinical and basic research in areas related to acquired defects of the head and neck by scholars at UCLA, the WCRB will become a regional and national resource for collaborative research, education, and patient care relevant to the treatment of these defects. In 1998, the School of Dentistry purchased and assumed ownership of 11,000 gross square feet of non-research space on two underground levels in the Center for Health Sciences complex. One of these levels is expressly dedicated as physical research space for the WCRB. This grant will provide matching funds for the construction of WCRB laboratories and core facilities and core facilities in support of research, as well as research training and education, within this dedicated space. The requested NCRR funding represents 35% of the total of the cost for the design, demolition, and construction of this facility, as well as for fixed core equipment necessary for the WCRB to attain its research, training and educational goals. The proposed laboratories will provide space for primary investigators, their research teams, and research collaborators, all of whom are conducting interdisciplinary investigation for craniofacial reconstruction.

加州大学洛杉矶分校牙科学院要求为Jane和Jerry Weintraub重建生物技术中心（WCRB）的发展提供资金，其明确目的是解决患者和卫生专业人员面临的恢复颅面复合体的重大挑战。具体来说，我们正在申请配套资金，用于将加州大学洛杉矶分校健康科学中心新获得的5,386平方英尺的空间转换为一个研究中心，该中心将WCRB安置在一个中央设施中。WCRB的形成是因为认识到继发于肿瘤消融、损伤或先天畸形的头颈部缺陷可能导致严重的功能障碍和面部畸形。WCRB的主要研究目标，即，颅面复合体的修复涉及伤口愈合的细胞和分子生物学研究、组织重塑和再生、生物材料和生物工程、一系列转化研究和临床结果研究。加州大学洛杉矶分校现有的种植和颌面修复学，整形和重建外科，头颈外科，整形外科，放射肿瘤学和皮肤科项目是我们独特能力的优势，并为快速持续增长提供了出色的潜力。基于加州大学洛杉矶分校学者在头颈部后天缺陷相关领域的临床和基础研究，WCRB将成为与这些缺陷治疗相关的合作研究，教育和患者护理的区域和国家资源。在1998年，牙科学院购买并承担了11,000总平方英尺的非研究空间的所有权在两个地下水平的中心健康科学复杂。其中一层专门用作WCRB的物理研究空间。这笔赠款将提供配套资金，用于在这一专用空间内建造WCRB实验室和核心设施以及支持研究的核心设施，以及研究培训和教育。要求的NCRR资金占该设施设计、拆除和建造费用总额的35%，以及WCRB实现其研究、培训和教育目标所需的固定核心设备。拟议的实验室将为主要研究人员，他们的研究团队和研究合作者提供空间，他们都在进行颅面重建的跨学科研究。

项目成果

期刊论文数量（48）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Three-dimensional bone-implant integration profiling using micro-computed tomography.

使用微型计算机断层扫描进行三维骨种植体一体化分析。

DOI：
发表时间：
2006
期刊：
The International journal of oral & maxillofacial implants
影响因子：
0
作者：
Butz,Frank;Ogawa,Takahiro;Chang,Ting-Ling;Nishimura,Ichiro
通讯作者：
Nishimura,Ichiro

Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats.

DOI：
10.1002/jbmr.23
发表时间：
2010-06
期刊：
JOURNAL OF BONE AND MINERAL RESEARCH
影响因子：
6.2
作者：
Hokugo, Akishige;Christensen, Russell;Chung, Evelyn M.;Sung, Eric C.;Felsenfeld, Alan L.;Sayre, James W.;Garrett, Neal;Adams, John S.;Nishimura, Ichiro
通讯作者：
Nishimura, Ichiro

Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery.

钛的非挥发性缓冲涂层可防止其生物老化并用于药物输送。

DOI：
10.1016/j.biomaterials.2010.02.061
发表时间：
2010
期刊：
Biomaterials
影响因子：
14
作者：
Suzuki,Takeo;Kubo,Katsutoshi;Hori,Norio;Yamada,Masahiro;Kojima,Norinaga;Sugita,Yoshihiko;Maeda,Hatsuhiko;Ogawa,Takahiro
通讯作者：
Ogawa,Takahiro

A genetic association study of single nucleotide polymorphisms in FGFR1OP2/wit3.0 and long-term atrophy of edentulous mandible.

DOI：
10.1371/journal.pone.0016204
发表时间：
2011-01-19
期刊：
PloS one
影响因子：
3.7
作者：
Suwanwela J;Lee J;Lin A;Ucer TC;Devlin H;Sinsheimer J;Garrett NR;Nishimura I
通讯作者：
Nishimura I

Prevalence of calcified carotid artery atheromas on the panoramic images of patients with syndrome Z, coexisting obstructive sleep apnea, and metabolic syndrome.

患有 Z 综合征、同时患有阻塞性睡眠呼吸暂停和代谢综合征的患者全景图像上钙化颈动脉粥样硬化的患病率。