EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION PROJECTS

加州大学洛杉矶分校牙科学院申请资金用于Jane and Jerry Weintraub重建生物技术中心（WCRB）的发展，其明确目的是解决患者和卫生专业人员在修复颅面复体方面面临的重大挑战。具体来说，我们正在请求相应的资金，将加州大学洛杉矶分校健康科学中心新获得的5386平方英尺的空间改造成一个研究综合体，将WCRB安置在一个中心设施中。WCRB的形成是由于人们认识到头颈部继发于肿瘤消融、损伤或先天性畸形的缺陷可导致严重的功能障碍和面部畸形。WCRB的主要研究目标，即颅面复合体的修复，涉及伤口愈合的细胞和分子生物学研究，组织重塑和再生，生物材料和生物工程，一系列转化研究和临床结果研究。加州大学洛杉矶分校现有的种植和颌面修复学、整形和重建外科、头颈外科、整形外科、放射肿瘤学和皮肤科等项目是我们独特能力的优势，并为快速持续增长提供了出色的潜力。在加州大学洛杉矶分校学者对头颈部获得性缺陷相关领域的临床和基础研究的基础上，WCRB将成为与这些缺陷治疗相关的合作研究、教育和患者护理的区域和国家资源。1998年，牙科学院购买并拥有了位于健康科学中心地下两层的11000平方英尺的非研究空间。其中一层被明确指定为WCRB的物理研究空间。这笔拨款将提供配套资金，用于建设WCRB实验室和核心设施，以及在这个专用空间内支持研究、研究培训和教育的核心设施。所要求的NCRR资金占该设施的设计、拆除和建造总费用的35%，以及WCRB实现其研究、培训和教育目标所需的固定核心设备。拟议的实验室将为主要研究者、他们的研究团队和研究合作者提供空间，他们都在进行颅面重建的跨学科研究。

The UCLA School of Dentistry requests funds for the development of the Jane and Jerry Weintraub Center for Reconstructive Biotechnology (WCRB), with the express purpose of addressing the substantial challenges of restoring the craniofacial complex facing both patients and health professionals. Specifically, we are requesting matching funds for the conversion of 5,386 gross square feet of newly-acquired space in the UCLA Center for Health Sciences into a research complex that houses the WCRB in one central facility. The WCRB has been formed out of recognition that defects in the head and neck secondary to tumor ablation, injury, or congenital malformation can result in severe functional impairment and facial disfigurement. The WCRB's primary research objective, i.e., restoration of the craniofacial complex, involves the study of cellular and molecular biology of wound healing, tissue remodeling and regeneration, biomaterials and bioengineering, a range of translational research, and clinical outcome studies. The existing programs at UCLA in implant and maxillofacial prosthodontics, plastic and reconstructive surgery, head and neck surgery, orthopedic surgery, radiation oncology and dermatology are the strength for our unique capabilities and offer outstanding potential for rapid continued growth. Building on the clinical and basic research in areas related to acquired defects of the head and neck by scholars at UCLA, the WCRB will become a regional and national resource for collaborative research, education, and patient care relevant to the treatment of these defects. In 1998, the School of Dentistry purchased and assumed ownership of 11,000 gross square feet of non-research space on two underground levels in the Center for Health Sciences complex. One of these levels is expressly dedicated as physical research space for the WCRB. This grant will provide matching funds for the construction of WCRB laboratories and core facilities and core facilities in support of research, as well as research training and education, within this dedicated space. The requested NCRR funding represents 35% of the total of the cost for the design, demolition, and construction of this facility, as well as for fixed core equipment necessary for the WCRB to attain its research, training and educational goals. The proposed laboratories will provide space for primary investigators, their research teams, and research collaborators, all of whom are conducting interdisciplinary investigation for craniofacial reconstruction.