VIVARIUM EXPANSION TO SUPPORT CARDIOPULMONARY RESEARCH

VIVARIUM 扩建以支持心肺研究

• 批准号: 6040934
• 负责人: Valerie K. Bergdall
• 金额: $ 88.57万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6040934
• 关键词: animal colony; biomedical facility; building /facility design /renovation

This construction project will allow for expansion of the Heart and Lung Institute animal facility at The Ohio State University. The Institute was recently established to promote interdisciplinary research in the field of heart and lung disease, two of the most frequent causes of mortality and morbidity in the United States. Research in these areas is dependent on the use of a variety of animal models, and therefore the animal resource program is a critical component of the success of these endeavors. We have identified a major deficiency in the amount of support space available for the Institute's animal research, and therefore are requesting expansion of the current facility to meet research needs. Rodents and large animals will be utilized in the research programs. This construction project, Phase 2, will provide for a large animal surgical suite, additional animal housing rooms, necropsy room, and carcass storage cooler. It will also allow separation of rodent and conventional animal housing thereby enhancing biosecurity for these research subjects. Phase 2 will be constructed in shell space located adjacent to the current animal facility (Phase 1), and used primarily for large animals for conventional disease status. Phase 1, for housing pathogen-free rodents, will require minor renovation to enhance biosecurity by providing a rodent surgical area within the animal facility, HEPA-filtered housing racks, and biosafety cabinets within the housing rooms. The expected outcome of this construction project is to enhance the research ability of investigators in the Heart and Lung Institute.

该建设项目将允许俄亥俄州州立大学的心肺研究所动物设施的扩建。该研究所最近成立，以促进心脏和肺部疾病领域的跨学科研究，这是美国死亡和发病的两个最常见原因。这些领域的研究依赖于各种动物模型的使用，因此动物资源计划是这些努力成功的关键组成部分。我们发现，研究所的动物研究在支持空间方面存在重大不足，因此要求扩大现有设施，以满足研究需要。啮齿动物和大型动物将用于研究计划。该建设项目（第2阶段）将提供一个大型动物手术室、额外的动物饲养室、尸检室和尸体储存冷却器。它还将允许将啮齿动物和传统动物隔离，从而加强这些研究对象的生物安全。第2阶段将在当前动物设施（第1阶段）附近的壳体空间内建造，主要用于治疗常规疾病状态的大型动物。第一阶段是饲养无病原体的啮齿动物，将需要进行小规模改造，通过在动物设施内提供啮齿动物手术区、HEPA过滤的饲养架和饲养室内的生物安全柜来加强生物安全。本建设项目的预期成果是提高心肺研究所研究人员的研究能力。