SFSTDS CRC

弗朗西斯科青少年和性传播疾病合作研究中心（SFCRC）的使命是通过开展高质量的跨学科研究，确定青少年中与性传播疾病（STD）相关的独特风险，并为STD研究人员创造一个富有成效的科学环境。我们将研究旧金山弗朗西斯科湾区受性病影响最严重的目标人群：居住在城市社区的非洲裔美国青少年。我们的跨学科重点包括强调青少年发展和感染的获得，包括风险因素，病毒性性病病原体的免疫学相关性，以及通过性伴侣网络传播感染。我们的具体目标是：1。通过描述决定疾病传播的性网络，包括识别预测风险的个人行为，描述疾病在人口一级的传播和传播特征（项目1：与青少年性网络有关的性传播疾病风险）。淋病和衣原体的传播，以及参与危险行为，将进行评估。2.确定与初始人乳头瘤病毒（HPV）感染相关的免疫因素，并确定预测感染持续性和随后发生鳞状上皮化生的宿主因素（项目2：初始HPV感染的免疫相关性）。3.确定与单纯疱疹病毒感染（HPV）相关的免疫因素，1型和2型，包括因素的作用，包括：疾病的获得，表现和自然史进展（项目3：HSV感染的流行病学和免疫生物学）。两个核心服务于这些项目：生物统计核心监督所有数据管理和分析。队列核心为中心项目的研究受试者招募、筛选、知情同意、入组和保留提供后勤支持。

The mission of the San Francisco Adolescents and Sexually Transmitted Diseases Cooperative Research Center (SFCRC) is to identify the unique risks associated with Sexually Transmitted Diseases (STDs) among adolescents through the conduct of high quality, interdisciplinary research and to foster a productive scientific environment for STD researchers. We will examine the target population most affected by STDs in the San Francisco Bay Area: African American adolescents living in urban neighborhoods. Our interdisciplinary focus includes an emphasis on adolescent development and the acquisition of infection, including risk factors, immunologic correlates of viral STD pathogens, and the diffusion of infection through networks of sexual partners. Our specific goals are to: 1. Characterize disease transmission and spread at the population level by characterizing a sexual network that determines disease spread, including identification of individual behaviors that predict risk (Project 1: STD Risks Associated with Adolescents' Sexual Networks). The dissemination of gonorrhea and chlamydia, as well as participation in risky behaviors, will be assessed. 2. Identify immunologic factors associated with initial human papillomavirus (HPV) infection and identify host factors predictive of persistence of infection and subsequent development of squamous metaplasia (Project 2: Immunologic Correlates of Initial HPV infection). 3. Identify immunologic factors associated with herpes simplex virus infections (HPV), types 1 and 2, including the role of factors including: acquisition, manifestation, and natural history progression of disease (Project 3: Epidemiology & Immunobiology of HSV infection). Two cores serve these projects: The Biostatistics Core oversees all data management and analyses. The Cohort Core provides logistical support for recruitment, screening, consent, enrollment, and retention of study subjects for center projects.