Combating MRSA; combining and increasing our understanding on colonisation, transmission and reservoirs will lead to control of infections by MRSA

对抗耐甲氧西林金黄色葡萄球菌（MRSA）；

• 批准号: MR/P028322/1
• 负责人: Jodi Lindsay
• 金额: $ 51.82万
• 依托单位: St George's, University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP028322%2F1
• 关键词: Combating; MRSA; combining; increasing; our

The underlying reasons for the epidemiological dynamics of MRSA clones in the hospital and the community are debated intensely and different explanations can be controversial. Most studies focus either on the genetic basis of the ability of MRSA to spread and be sustained, like the presence of PVL, SCCmec type IV etc. or on the epidemiological features, like risk groups, selection due to antibiotic use, or prevention measures in health care centres. After introduction of new strains, antibiotic or disinfectant use is an important driving force, prevention should be focused on that point. When selected strains are more able to spread due to their genetic profile, measures should be developed targeted on prevention of transmission of these particular strains. However, a combination of driving forces will be often present. In short, this study will create more insight into the success and failure of MRSA, and together with the mathematical model, will target specific and realistic tools to prevent further spreading and thus disease. This accounts both for hospitalized patients and in otherwise healthy individuals, as present in the large uncontrolled epidemic by USA300. MACOTRA will join approaches on understanding the epidemiology of MRSA together, will add the host-factor and herewith aims to explain the epidemiological behaviour of MRSA in its rise, maintenance or disappearance. We believe that only by combining all these aspects, we can understand the epidemiology and thus design optimal and focused prevention measures.

MRSA 克隆在医院和社区流行病学动态的根本原因存在激烈争论，不同的解释可能存在争议。大多数研究要么关注 MRSA 传播和持续能力的遗传基础，例如 PVL、SCCmec IV 型等的存在，要么关注流行病学特征，例如风险群体、抗生素使用导致的选择或卫生保健中心的预防措施。新菌株引入后，抗生素或消毒剂的使用是重要推动力，预防应重点关注这一点。当选定的菌株因其遗传特征而更容易传播时，应制定有针对性的措施来预防这些特定菌株的传播。然而，往往会同时存在多种驱动力。简而言之，这项研究将更深入地了解 MRSA 的成功和失败，并与数学模型一起，将针对具体和现实的工具来防止进一步传播，从而防止疾病。这既适用于住院患者，也适用于其他健康个体，正如 USA300 大规模不受控制的流行病中所出现的那样。 MACOTRA 将把理解 MRSA 流行病学的方法结合在一起，添加宿主因素，旨在解释 MRSA 的流行病学行为，包括其上升、维持或消失。我们相信，只有结合这些方面，我们才能了解流行病学，从而设计出最佳的、有针对性的预防措施。

项目成果

Correction for Leclerc et al., "Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage".

• DOI: 10.1128/msystems.00974-22
• 发表时间: 2023-02-23
• 期刊: mSystems
• 影响因子: 6.4

The dual nature of bacteriophage: growth-dependent predation and generalised transduction of antimicrobial resistance

噬菌体的双重性质：生长依赖性捕食和抗菌素耐药性的普遍转导

• DOI: 10.1101/2021.07.24.453184
• 发表时间: 2021
• 作者: Leclerc Q

Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage.

• DOI: 10.1128/msystems.00135-22
• 发表时间: 2022-04-26
• 期刊: mSystems
• 影响因子: 6.4

Dehydration Tolerance in Epidemic versus Nonepidemic MRSA Demonstrated by Isothermal Microcalorimetry.

• DOI: 10.1128/spectrum.00615-22
• 发表时间: 2022-10-26
• 期刊: MICROBIOLOGY SPECTRUM
• 影响因子: 3.7
• 作者: Baede, Valerie O.;Tavakol, Mehri;Vos, Margreet C.;Knight, Gwenan M.;van Wamel, Willem J. B.
• 通讯作者: van Wamel, Willem J. B.

Markers of epidemiological success of methicillin-resistant Staphylococcus aureus isolates in European populations.

• DOI: 10.1016/j.cmi.2023.05.015
• 发表时间: 2023-09
• 期刊: CLINICAL MICROBIOLOGY AND INFECTION
• 影响因子: 14.2
• 作者: Baede, Valerie O.;Gupta, Arya;Knight, Gwenan M.;Schouls, Leo M.;Laing, Ken;Tavakol, Mehri;Barray, Anais;de Vlas, Sake J.;de Vos, Anneke S.;Hendrickx, Antoni P. A.;Khan, Madeeha;Kretzschmar, Mirjam E.;van Wamel, Willem J. B.;Lina, Gerard;Vandenesch, Francois;Vos, Margreet C.;Witney, Adam A.;Rasigade, Jean-Philippe;Lindsay, Jodi A.
• 通讯作者: Lindsay, Jodi A.