课题基金 / 基金详情

EARLY EXPERIENCE AND NEURODEGENERATION

EARLY EXPERIENCE AND NEURODEGENERATION
早期经历和神经退行性变
批准号:
6055845
负责人:
Michael Leon
金额:
$30.34万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-01 至 2003-08-31

项目摘要

项目成果

Michael Leon的其他基金

相关文献

中文摘要
翻译
描述:早期嗅觉体验的变化可能会产生深远的影响。 影响发育过程中存活的神经元数量。增强 出生后早期发育过程中的感觉经历可以诱导 嗅球神经元增加和早期嗅觉限制 刺激嗅球神经元的细胞死亡。因此,在本发明中, 感觉刺激的变化可以诱导或抑制细胞凋亡, 发育并影响靶组织中神经元的数量。在 在其他系统中,Bcl-2已被证明是一种阻断凋亡的蛋白质, 细胞死亡,并且在嗅觉体中,BCL-2的mRNA在 嗅觉受限的出生后大鼠嗅球。拟议的实验 将检验凋亡性细胞死亡增加的假设, 在气味受限的大鼠和小鼠幼崽中。其他实验将测试 假设Bcl-2蛋白在以下两个过程中起着关键作用: 保护或促进发育过程中的正常细胞死亡, 早期嗅觉限制诱导的细胞死亡。另外的实验 将测试一个假设,即在增强的细胞死亡减少, 早期嗅觉体验发生在Bcl-2介导的机制中, 蛋白质家族
英文摘要
DESCRIPTION: A change in early olfactory experience can have profound affects on the number of neurons that survive during development. Enhanced sensory experience during early post-natal development can induce an increase in olfactory bulb neurons, and early olfactory restriction stimulates cell death in a population of olfactory bulb neurons. Thus, changes in sensory stimulation may induce or suppress apoptosis during development and influence the number of neurons in target tissues. In other systems, Bcl-2 has been shown to be a protein that blocks apoptotic cell death, and in the olfactory bulk, the mRNA for BCL-2 is elevated in oder-restricted postnatal rat olfactory bulbs. The proposed experiments will test the hypothesis that there is an increase in apoptotic cell death in odor-restricted rat and mouse pups. Other experiments will test the hypothesis that the Bcl-2 protein plays a critical role in either protecting or promoting normal cell death during development and increased cell death induced by early olfactory restriction. Additional experiments will test the hypothesis that a reduction in cell death during enhanced early olfactory experience occurs during a mechanism mediated by the Bcl-2 protein family.
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TREATMENT FOR AUTISM
Neuroinformatic Analysis of Olfactory Coding
  • 批准号:
    7068069
  • 项目类别:
  • 资助金额:
    $25.73万
  • 财政年份:
    2004
  • 负责人:
    Michael Leon
  • 依托单位:
Neuroinformatic Analysis of Olfactory Coding
  • 批准号:
    6803809
  • 项目类别:
  • 资助金额:
    $26.23万
  • 财政年份:
    2004
  • 负责人:
    Michael Leon
  • 依托单位:
Neuroinformatic Analysis of Olfactory Coding
  • 批准号:
    6937143
  • 项目类别:
  • 资助金额:
    $26.37万
  • 财政年份:
    2004
  • 负责人:
    Michael Leon
  • 依托单位: