PERIODONTAL INFECTION AND RISK FOR MYOCARDIAL INFARCTION

牙周感染和心肌梗死的风险

• 批准号: 2882727
• 负责人: Robert J Genco
• 金额: $ 25.86万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2882727
• 关键词: Actinobacillus actinomycetemcomitans; African American; Bacteroides gingivalis; Capnocytophaga; Fusobacterium nucleatum; Streptococcus sanguis; age difference; alcoholism /alcohol abuse; behavioral /social science research tag; caucasian American; clinical research; dietary constituent; disease /disorder proneness /risk; gender difference; human population study; human subject; laboratory rabbit; myocardial infarction; nutrition related tag; oral bacteria; periodontitis; platelet aggregation; psychological stressor; substance abuse related disorder; tobacco abuse

We propose a comprehensive evaluation of the reported association between periodontal infections and myocardial infarction. Periodontal diseases, which are caused by bacteria and associated with increased prevalence and severity of bacteremia, may represent significant, previously unrecognized risk for coronary artery disease. The bacteremias associated with periodontal infections often involve bacteria with the ability to aggregate platelets and stimulate cells involved in atheromatous plaque formation. Hence, frequent bacteremia with subgingival plaque bacteria may increase the chances of thromboembolic events leading to myocardial infarction. Our specific aims include: 1) To evaluate the association between myocardial infarction and infectious periodontal disease in a population based case-control study, and 2) To evaluate the association between myocardial infarction and the subgingival microflora associated with infectious periodontitis including organisms such as S. sanguis and P. gingivalis which express platelet associated aggregation protein. The dependent variable, or outcome of interest, will be documented non-fatal myocardial infarction in approximately 960 cases, 35 to 69 years of age, compared to 2200 age-matched controls. Cases and controls will include blacks and whites of both genders who are being assembled at the University at Buffalo for a study of myocardial infarction and alcohol consumption. We propose adding an oral health component to this funded study, clarifying the relationship between the exposures of interest, destructive periodontitis and the subgingival microflora, and coronary artery disease, specifically myocardial infarction. We will systematically evaluate the role of multiple confounders and co-risk factors such as smoking, age, diet, and alcohol use. The proposed study will help clarify the relationship between periodontal disease and myocardial infarction. Detailed evaluation of the potential of chronic infections such as periodontal disease to contribute to the risk of myocardial infarction is important, since cardiovascular disease remains a leading cause of death in most developed countries. Furthermore, periodontal disease is one of the most common infections of man. Therefore, understanding the association between these two diseases is of significant importance, both to individuals and for public health measures directed to reducing their morbidity and mortality.

我们建议全面评估报告的关联， 牙周感染和心肌梗塞。 牙周病， 这些疾病是由细菌引起的， 菌血症的严重程度，可能代表显著的，以前未被认识到的 冠心病的风险。 与之相关的细菌 牙周感染通常涉及具有以下能力的细菌 聚集血小板并刺激参与动脉粥样硬化斑块的细胞 阵 因此，经常菌血症与龈下菌斑细菌 可能会增加血栓栓塞事件导致心肌梗死的机会， 梗塞 我们的具体目标包括：1）评估之间的关联 心肌梗死与感染性牙周病 基于病例对照研究，和2）评估之间的关联 心肌梗死和龈下微生物区系与 传染性牙周炎，包括链球菌等生物。sanguis和P. 表达血小板相关聚集蛋白。 的 因变量或关注的结局将记录为非致死性 心肌梗死约960例，年龄35 - 69岁， 与2200名年龄匹配的对照组相比。 病例和对照将包括 黑人和白人的男女谁是聚集在 布法罗大学的一项关于心肌梗塞和酒精的研究 消费 我们建议在这项资助计划中加入口腔健康部分， 研究，澄清感兴趣的暴露之间的关系， 破坏性牙周炎和龈下菌群，以及冠状动脉 动脉疾病，特别是心肌梗死。 我们将 系统地评估多种混杂因素和共同风险的作用 吸烟、年龄、饮食和饮酒等因素。 这项研究将有助于阐明牙周炎与 疾病和心肌梗死。 潜力的详细评估 慢性感染，如牙周病，有助于 心肌梗死的风险很重要，因为心血管疾病 仍然是大多数发达国家的主要死因。 此外，牙周病是最常见的感染之一， 伙计 因此，了解这两种疾病之间的联系 对个人和公众健康都具有重要意义 旨在降低其发病率和死亡率的措施。