PERIODONTAL INFECTION AND RISK FOR MYOCARDIAL INFARCTION

我们建议对所报告的关联性进行综合评估 牙周感染和心肌梗塞。 牙周疾病， 这是由细菌引起的，与患病率增加有关， 菌血症的严重程度，可能代表显着的、以前未被认识到的 冠状动脉疾病的风险。 相关菌血症 牙周感染通常涉及具有以下能力的细菌： 聚集血小板并刺激参与粥样斑块的细胞 形成。 因此，龈下菌斑细菌经常引起菌血症 可能会增加血栓栓塞事件导致心肌梗死的机会 梗塞。 我们的具体目标包括：1）评估之间的关联 人群中的心肌梗塞和感染性牙周病 基于病例对照研究，2) 评估之间的关联 心肌梗死和与之相关的龈下微生物区系 感染性牙周炎，包括血链球菌和丙酸杆菌等生物体。 牙龈杆菌表达血小板相关聚集蛋白。 的 因变量或感兴趣的结果将被记录为非致命的 约960例心肌梗塞，年龄35至69岁， 与 2200 名年龄匹配的对照组相比。 案例和控制将包括 聚集在广场的黑人和白人 布法罗大学进行心肌梗塞和酒精研究 消费。 我们建议在此资助的项目中添加口腔健康部分 研究，澄清感兴趣的暴露之间的关系， 破坏性牙周炎和龈下微生物区系以及冠状动脉 动脉疾病，特别是心肌梗塞。 我们会 系统地评估多种混杂因素和共同风险的作用 吸烟、年龄、饮食和饮酒等因素。 拟议的研究将有助于阐明牙周病之间的关系 疾病和心肌梗塞。 潜力的详细评估 牙周病等慢性感染的发生 心肌梗塞的风险很重要，因为心血管疾病 仍然是大多数发达国家死亡的主要原因。 此外，牙周病是最常见的感染之一 男人。 因此，了解这两种疾病之间的关联 对个人和公共卫生都具有重要意义 旨在降低其发病率和死亡率的措施。

We propose a comprehensive evaluation of the reported association between periodontal infections and myocardial infarction. Periodontal diseases, which are caused by bacteria and associated with increased prevalence and severity of bacteremia, may represent significant, previously unrecognized risk for coronary artery disease. The bacteremias associated with periodontal infections often involve bacteria with the ability to aggregate platelets and stimulate cells involved in atheromatous plaque formation. Hence, frequent bacteremia with subgingival plaque bacteria may increase the chances of thromboembolic events leading to myocardial infarction. Our specific aims include: 1) To evaluate the association between myocardial infarction and infectious periodontal disease in a population based case-control study, and 2) To evaluate the association between myocardial infarction and the subgingival microflora associated with infectious periodontitis including organisms such as S. sanguis and P. gingivalis which express platelet associated aggregation protein. The dependent variable, or outcome of interest, will be documented non-fatal myocardial infarction in approximately 960 cases, 35 to 69 years of age, compared to 2200 age-matched controls. Cases and controls will include blacks and whites of both genders who are being assembled at the University at Buffalo for a study of myocardial infarction and alcohol consumption. We propose adding an oral health component to this funded study, clarifying the relationship between the exposures of interest, destructive periodontitis and the subgingival microflora, and coronary artery disease, specifically myocardial infarction. We will systematically evaluate the role of multiple confounders and co-risk factors such as smoking, age, diet, and alcohol use. The proposed study will help clarify the relationship between periodontal disease and myocardial infarction. Detailed evaluation of the potential of chronic infections such as periodontal disease to contribute to the risk of myocardial infarction is important, since cardiovascular disease remains a leading cause of death in most developed countries. Furthermore, periodontal disease is one of the most common infections of man. Therefore, understanding the association between these two diseases is of significant importance, both to individuals and for public health measures directed to reducing their morbidity and mortality.