PERIODONTAL INFECTION AND RISK FOR MYOCARDIAL INFARCTION

我们建议对已报道的两者之间的关联进行全面评估 牙周感染和心肌梗死。牙周病， 它们是由细菌引起的，与增加的流行率和 菌血症的严重程度，可能代表着严重的，以前没有认识到的 有患冠状动脉疾病的风险。与之相关的细菌症 牙周感染通常涉及具有以下能力的细菌 聚集血小板和刺激细胞参与动脉粥样硬化斑块 队形。因此，频繁的菌血症与龈下菌斑细菌有关 可能会增加血栓栓塞症导致心肌梗死的几率 脑梗塞。 我们的具体目标包括：1)评估两者之间的联系 人群中的心肌梗死和感染性牙周病 以病例对照研究为基础，2)评价 心肌梗死与牙周炎相关菌群的研究 感染性牙周炎包括血链球菌和P. 表达血小板相关聚集蛋白的牙周炎。这个 因变量或感兴趣的结果将被记录为非致命的 约960例心肌梗塞患者，年龄在35岁到69岁之间， 相比之下，年龄匹配的对照组为2200人。病例和控制措施将包括 黑人和白人，无论男女，都聚集在 布法罗大学对心肌梗死和酒精的研究 消费。我们建议在这笔资金中增加一个口腔健康部分 研究，澄清利益暴露之间的关系， 破坏性牙周炎与龈下微生物区系及冠状 动脉疾病，特别是心肌梗塞。我们会 系统评估多个混杂因素和共同风险的作用 吸烟、年龄、饮食和饮酒等因素。 这项拟议的研究将有助于澄清牙周与牙周的关系 疾病和心肌梗塞。对潜力的详细评估 慢性感染，如牙周病，导致 心肌梗死的风险很重要，因为心血管疾病 在大多数发达国家，这仍然是主要的死亡原因。 此外，牙周病是最常见的感染之一。 天哪。因此，了解这两种疾病之间的联系 对个人和公共卫生都具有重要意义 旨在降低其发病率和死亡率的措施。

We propose a comprehensive evaluation of the reported association between periodontal infections and myocardial infarction. Periodontal diseases, which are caused by bacteria and associated with increased prevalence and severity of bacteremia, may represent significant, previously unrecognized risk for coronary artery disease. The bacteremias associated with periodontal infections often involve bacteria with the ability to aggregate platelets and stimulate cells involved in atheromatous plaque formation. Hence, frequent bacteremia with subgingival plaque bacteria may increase the chances of thromboembolic events leading to myocardial infarction. Our specific aims include: 1) To evaluate the association between myocardial infarction and infectious periodontal disease in a population based case-control study, and 2) To evaluate the association between myocardial infarction and the subgingival microflora associated with infectious periodontitis including organisms such as S. sanguis and P. gingivalis which express platelet associated aggregation protein. The dependent variable, or outcome of interest, will be documented non-fatal myocardial infarction in approximately 960 cases, 35 to 69 years of age, compared to 2200 age-matched controls. Cases and controls will include blacks and whites of both genders who are being assembled at the University at Buffalo for a study of myocardial infarction and alcohol consumption. We propose adding an oral health component to this funded study, clarifying the relationship between the exposures of interest, destructive periodontitis and the subgingival microflora, and coronary artery disease, specifically myocardial infarction. We will systematically evaluate the role of multiple confounders and co-risk factors such as smoking, age, diet, and alcohol use. The proposed study will help clarify the relationship between periodontal disease and myocardial infarction. Detailed evaluation of the potential of chronic infections such as periodontal disease to contribute to the risk of myocardial infarction is important, since cardiovascular disease remains a leading cause of death in most developed countries. Furthermore, periodontal disease is one of the most common infections of man. Therefore, understanding the association between these two diseases is of significant importance, both to individuals and for public health measures directed to reducing their morbidity and mortality.