ECHOCARDIOGRAPHIC ASSESSMENT OF MICROVASCULAR PERFUSION

微血管灌注的超声心动图评估

基本信息

  • 批准号:
    2726661
  • 负责人:
  • 金额:
    $ 12.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1999
  • 资助国家:
    美国
  • 起止时间:
    1999-01-10 至 2003-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: (Adapted from applicant's abstract) The principal investigator (P.I.) for this award application has previously been productive in developing research and clinical applications for myocardial contrast echocardiography (MCE). This past research provided the P.I. with a basic understanding of ultrasound physics, coronary physiology and perfusion imaging. MCE uses microbubbles as a contrast agent during simultaneous ultrasound imaging, and has recently developed into a unique tool for the quantification of myocardial blood flow (MBF) and myocardial blood volume (MBV). Using both intracoronary injections, and continuous intravenous infusions of micro-bubbles, MCE also has the ability to discriminate between extramyocardial and capillary sites of MBF control. An improvement in our understanding of the adaptive microcirculatory changes associated with coronary artery disease (CAD) could potentially allow earlier identification of patients with this disease. The specific aims in this proposal are therefore to assess adaptive changes in MBV, the transmural distribution of MBF, and phasic changes in MBF in the setting of CAD. Acute and chronic animal models that simulate CAD in humans, and patients undergoing coronary angiography, will be used to evaluate microvascular sites of autoregulation in the setting of CAD. In the presence of exogenous hyperemia, capillaries may collapse in the bed distal to the stenosis. The physiologic basis for this occurrence, and the basis for stenosis detection using non-invasive perfusion imaging will be assessed. The transmural distribution of flow is inhomogeneous, and is related to differences in intramyocardial pressure and oxygen demands in different myocardial layers. Determining the endocardial/epicardial distribution of MBF and MBV could provide an unique way to both detect and quantify stenosis seventy. Similarly, phasic changes in coronary blood flow are influenced by myocardial function, coronary perfusion pressure, and the state of the microcirculation. Studies using MCE to evaluate phasic flow patterns in the setting of CAD, both at rest and during exogenous pharmacologic stimulation will be performed. The ultimate goal of this research is to gain a better understanding of the coronary microcirculation that will allow improved non-invasive diagnosis of CAD. The protocols outlined above require a comprehensive understanding of myocardial microcirculatory physiology, microvascular perfusion, mathematical modeling and ultrasound physics, for which Sanjiv Kaul, M.D. will serve as mentor. Furthermore, if the hypotheses of the current proposal are correct, MCE will offer novel insights into microvascular physiology that are currently not attainable with other non-invasive imaging methods, and will provide new diagnostic modalities for Cardiology.
描述:(改编自申请者摘要) 首席调查员(P.I.)对于这个奖项的申请已经 以前在开发研究和临床方面卓有成效 心肌声学造影(MCE)的应用。这段往事 研究使私家侦探对超声波有了基本的了解 物理学、冠状动脉生理学和灌注成像。MCE使用 微泡在同时超声成像过程中作为造影剂, 最近已经发展成为一种独特的工具,用于量化 心肌血流量(MBF)和心肌血容量(MBV)。vbl.使用 无论是冠状动脉内注射,还是持续静脉滴注 微气泡,MCE也有能力区分 MBF对照的心肌外和毛细血管部位。在…方面的改进 我们对适应性微循环变化的理解 冠状动脉疾病(CAD)可能会更早 对患有这种疾病的患者的鉴定。其中的具体目标是 因此,建议评估MBV的适应性变化,即跨壁 在CAD设置中,MBF的分布和MBF的阶段性变化。 模拟人类CAD的急性和慢性动物模型,以及 接受冠状动脉造影术的患者将被用于评估 冠心病环境中自身调节的微血管部位。在 存在外源性充血,毛细血管可能塌陷在床上。 在狭窄的远侧。发生这种情况的生理基础,以及 无创灌注成像检测狭窄的基础 将会被评估。血流的跨壁分布是不均匀的, 与心肌内压和血氧的差异有关 不同心肌层的需求。确定 MBF和MBV在心内膜/心外膜的分布可提供 独一无二的方法来检测和量化狭窄70。同样, 心肌梗死对冠脉血流时相变化的影响 功能、冠脉灌注压和心脏的状态 微循环。用MCE评价相态流型的研究 在CAD的环境中,无论是在静息状态下还是在外源性药物作用期间 将进行刺激。 这项研究的最终目的是为了更好地了解 冠状动脉微循环将允许改善非侵入性 冠心病的诊断。上面概述的协议需要全面的 对心肌微循环生理、微血管的认识 灌注、数学建模和超声物理,为此 Sanjiv Kaul医学博士将担任导师。此外,如果假设 目前的提议是正确的,MCE将为 微血管生理学,目前不能用其他 无创成像方法,并将提供新的诊断模式 心脏病学的。

项目成果

期刊论文数量(0)
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会议论文数量(0)
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KEVIN S WEI其他文献

KEVIN S WEI的其他文献

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{{ truncateString('KEVIN S WEI', 18)}}的其他基金

MYOCARDIAL FLOW RESERVE AS A PROGNOSTIC MARKER IN DILATED CARDIOMYOPATHY
心肌血流储备作为扩张型心肌病的预后标志
  • 批准号:
    7205510
  • 财政年份:
    2005
  • 资助金额:
    $ 12.66万
  • 项目类别:
ECHOCARDIOGRAPHIC ASSESSMENT OF MICROVASCULAR PERFUSION
微血管灌注的超声心动图评估
  • 批准号:
    6490285
  • 财政年份:
    1999
  • 资助金额:
    $ 12.66万
  • 项目类别:
ECHOCARDIOGRAPHIC ASSESSMENT OF MICROVASCULAR PERFUSION
微血管灌注的超声心动图评估
  • 批准号:
    6343302
  • 财政年份:
    1999
  • 资助金额:
    $ 12.66万
  • 项目类别:
ECHOCARDIOGRAPHIC ASSESSMENT OF MICROVASCULAR PERFUSION
微血管灌注的超声心动图评估
  • 批准号:
    6627299
  • 财政年份:
    1999
  • 资助金额:
    $ 12.66万
  • 项目类别:
ECHOCARDIOGRAPHIC ASSESSMENT OF MICROVASCULAR PERFUSION
微血管灌注的超声心动图评估
  • 批准号:
    6138927
  • 财政年份:
    1999
  • 资助金额:
    $ 12.66万
  • 项目类别:
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