A STRATEGY TO PREVENT IRON OVERLOAD IN HEMOCHROMATOSIS

预防血色病铁过量的策略

• 批准号: 6074646
• 负责人: MORTEZA JANGHORBANI
• 金额: $ 13.22万
• 依托单位: BIOCHEMANALYSIS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6074646
• 关键词: clinical research; dietary constituent; dietary supplements; food science /technology; gastrointestinal absorption /transport; hereditary hemochromatosis; human subject; iron metabolism; iron poisoning; male; nutrition related tag; tannins

The approach is to develop an effective strategy for prevention of iron overload in high-risk candidates for hereditary hemochromatosis. The strategy is based on integration of a dietary inhibitor of non-heme iron absorption, with an effective means for early selection of high-risk candidates, and monitoring of the life-long effectiveness of the strategy. Selection of high-risk candidates is based on actual measurement of dietary non-heme iron absorption in genotypically selected individuals, using a non-radioactive isotope technique. Effective monitoring is based on periodic measurement of dietary non-heme iron absorption throughout life using this non-radioactive technique in relation to observed changes in iron stores. During Phase I, the overall feasibility of this approach will be assessed in six male human subjects (HHC patients) by assessing the central component of the integrated strategy, that an effective inhibitor for life-long inhibition of dietary non-heme iron in these subjects. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

方法是制定有效的策略来预防 遗传性血色素沉着病高危人群的铁超载。这 该策略基于非血红素铁膳食抑制剂的整合 吸收，是早期选择高危人群的有效手段 候选人，并监测该战略的终身有效性。 高风险候选人的选择是基于实际饮食测量 使用基因型选择的个体的非血红素铁吸收 非放射性同位素技术。有效的监测基于定期 使用此方法测量一生中膳食非血红素铁的吸收 与观察到的铁储备变化相关的非放射性技术。 在第一阶段，将评估该方法的总体可行性 通过评估六名男性人类受试者（HHC 患者）的核心组成部分 综合策略，即终身抑制的有效抑制剂 这些受试者中膳食非血红素铁的含量。 拟议的商业应用：不可用