A STRATEGY TO PREVENT IRON OVERLOAD IN HEMOCHROMATOSIS

方法是制定一项有效的战略来预防 遗传性血色素沉着症高危候选人群铁超载。这个 策略的基础是整合一种非血红素铁的饮食抑制剂 吸收，早期选择高危人群的有效手段 候选人，并监测该战略的终身效力。 高危候选人的选择是基于对饮食的实际测量 基因选择的个体中非血红素铁的吸收，使用 非放射性同位素技术。有效的监测是以定期为基础的 用这项技术测量一生中饮食中非血红素铁的吸收 与观察到的铁储存变化有关的非放射性技术。 在第一阶段，将于#年评估这一方法的总体可行性。 六名男性受试者(HHC患者)通过评估中枢成分 综合策略，即有效的终身抑制抑制剂 在这些受试者中饮食中非血红素铁的含量。 建议的商业应用：不可用

The approach is to develop an effective strategy for prevention of iron overload in high-risk candidates for hereditary hemochromatosis. The strategy is based on integration of a dietary inhibitor of non-heme iron absorption, with an effective means for early selection of high-risk candidates, and monitoring of the life-long effectiveness of the strategy. Selection of high-risk candidates is based on actual measurement of dietary non-heme iron absorption in genotypically selected individuals, using a non-radioactive isotope technique. Effective monitoring is based on periodic measurement of dietary non-heme iron absorption throughout life using this non-radioactive technique in relation to observed changes in iron stores. During Phase I, the overall feasibility of this approach will be assessed in six male human subjects (HHC patients) by assessing the central component of the integrated strategy, that an effective inhibitor for life-long inhibition of dietary non-heme iron in these subjects. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE