SCHIZOPHRENIA RESEARCH TRAINING

这一培训计划的总体目的是增加精神分裂症领域的研究人员数量，他们有能力应用现代研究技术，并有能力将神经科学的最新发展纳入他们的研究中。精神药理学、神经化学、遗传学、神经病理学、脑成像、神经心理学、神经生物学服务研究和流行病学等学科的培训将由积极从事精神分裂症相关研究的参与教员提供。所有导师都有目前由联邦政府资助的研究。培训将通过监督参与这项正在进行的研究来发展研究技能，但受训者也将被期望构建和执行独立的项目。教学工作将集中在研究设计和统计上。为研究员、教职员工和特邀嘉宾举办的精神分裂症研究研讨会回顾了当前所有领域的精神分裂症研究。该项目的受训人员将主要是完成医学院培训和四年住院医生培训的精神科医生。这些受训人员将在诊断和治疗包括精神分裂症在内的主要精神疾病方面拥有相当丰富的经验，但可能缺乏具体的研究技能，如制定可检验的假设、设计研究所审查委员会可以接受的可行研究研究，以及收集和分析标准化研究数据。除了这些MD精神病学家，我们预计我们将招聘具有基础科学研究背景的MD/博士，以及对精神分裂症感兴趣的博士心理学家或神经科学家。我们将根据他们的背景和兴趣调整培训，包括为他们提供精神分裂症临床现象学方面的培训。支持期限最长为四年，每年选择两到三名新研究员。这项计划将在纽约州精神病学研究所(PI)和/或纽约皇后区的Creedmoor精神病学中心(CPC)由哥伦比亚大学的教职员工在这些机构进行。拥有每年大约7000万美元的联邦拨款、纽约州在PI资助的一个拥有70个床位(包括12个指定的精神分裂症住院研究单位)的研究机构、同样得到资助的CPC的24个研究床位、一个休斯研究所和4个MHCRC，这里有研究人员和临床设施来执行这一拟议的培训计划，到目前为止，其培训工作取得了很大的成功。精神分裂症是一种毁灭性的疾病，也是一个主要的公共卫生问题。据估计，0.8%的人口最终会患上这种疾病，所有医院床位的四分之一都被这类患者占据。这种疾病通常会削弱或破坏患者的生产性工作能力。除了它带来的个人恐惧、困惑和痛苦之外，家庭成员也面临着巨大的压力。很大一部分无家可归者(15%-40%)被发现患有精神分裂症，可能有一种较轻微的疾病没有包括在上述数字中，这也会导致严重的社会和职业残疾。

The overall purpose of this training program is to increase the number of researchers in the area of schizophrenia who have an ability to apply modern techniques of research and an ability to incorporate recent developments in neuroscience into their investigations. Training in the disciplines of psychopharmacology, neurochemistry, genetics, neuropathology, brain imaging, neuropsychology, neurobiology services research and epidemiology will be offered by participating faculty actively engaged in schizophrenia-related research. All mentors have current federally funded research. The training will develop research skills by supervised participation in this ongoing research, but the trainee will be expected to construct and execute independent projects as well. Didactic work will focus on research design and statistics. A schizophrenia research seminar for fellows, faculty and invited guests reviews current schizophrenia research in all areas. Trainees for the project will primarily be psychiatrists who have completed both their medical school training and four year of residency. These trainee will have had considerable experience with the diagnosis and treatment of major psychiatric disorder, including schizophrenia, but are likely to lack specific research skills such as developing testable hypotheses, designing feasible research studies acceptable to institute review boards, and the collection and analysis of standardized research data. In addition to these MD psychiatrists, we expect that we will recruit MD/PhDs with a background in basic science research, and PhD psychologists or neuroscientists with an interest in schizophrenia. We will adapt the training to suit their backgrounds and interests, including offering them training in the clinical phenomenology of schizophrenia. Support is available for up to four years, with two to three new fellows chosen each year. This program will be conducted at the New York State Psychiatric Institute (PI) and/or the Creedmoor Psychiatric Center (CPC) in Queens, New York, by faculty members of Columbia University at these institutions. With a total of approximately seventy million dollars annually in federal grants, a research institute with 70 beds (including a 12 designated schizophrenia inpatient research unit) funded by New York State at PI, 24 research beds at CPC similarly funded, a Hughes Institute and 4 MHCRCs, there exists the research personnel and clinical facilities to execute this proposed training program, which has had excellent success in its training efforts thus far. Schizophrenia is a devastating illness and a major public health problem. It is estimated that 0.8% of the population will eventually develop this disorder, and that one quarter of all hospital beds are occupied by such patients. This illness typically diminishes or destroys the patient's capabilities for productive work. In addition to the personal terror, confusion, and misery that it produces, there is a tremendous stress on family members. A significant portion (15-40%) of homeless individuals have been found to be schizophrenic, and it is possible that there is a milder form of the illness not included in the above figures, which also causes significant social and occupational disability.