HORMONE REPLACEMENT EFFECTS ON FRONTAL LOBE FUNCTION

激素替代对额叶功能的影响

• 批准号: 2757732
• 负责人: DOMONICK J WEGESIN
• 金额: $ 8.53万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2757732
• 关键词: age difference; behavior test; behavioral /social science research tag; brain electrical activity; clinical research; cognition; electroencephalography; electrooculography; electrophysiology; estrogens; evoked potentials; female; frontal lobe /cortex; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; judgment; memory; neuropsychological tests; neuropsychology; performance; postmenopause; psychological aspect of aging; women's health

Memory loss is one of the main complaints among healthy elders. Recent evidence suggests that hormonal changes accompanying menopause may partly account for memory-loss in aging women and that these memory effects can be tempered by the use of hormone replacement therapy (HRT). The mechanism of these cognitive benefits remains unclear. Two major neuropsychological hypotheses used to account for cognitive aging phenomena suggest that either frontal lobe deficits or medial temporal lobe deficits may be involved in the HRT memory effects. The current project will explore whether HRT memory enhancement is better characterized as secondary to a change in frontal lobe, as opposed to medial temporal lobe, function. In addition to examining the effects of HRT on memory, the proposed studies will also investigate normal age- associated memory impairment. Specifically, healthy postmenopausal women drawn from a representative community sample who have undergone long-term HRT and age-matched controls who have never used HRT will be compared to younger premenopausal women on a recognition memory task. To dissociate better the neural mechanisms by which HRT modulates memory function, event- related brain potentials (ERPs) will be recorded from 64 scalp sites during the memory task. Further, neuropsychological measures thought to tap frontal and medial temporal lobe function will be collected and correlated with behavioral and electrophysiological indices of memory as convergent evidence for the dissociation between frontal and medial temporal lobe involvement. Overall, this work will serve as a means to better elucidate the type of memory changes associated with HRT and aging and to provide an initial examination of brain-behavior associations related to the memory effects reported in HRT-using postmenopausal women.

记忆力减退是健康老年人的主要抱怨之一。最近的证据表明，更年期伴随的激素变化可能部分解释了老年妇女的记忆丧失，这些记忆影响可以通过使用激素替代疗法（HRT）来缓和。这些认知益处的机制尚不清楚。用于解释认知老化现象的两个主要神经心理学假设表明，额叶缺陷或内侧颞叶缺陷可能与HRT记忆效应有关。目前的项目将探索HRT记忆增强是否更好地表征为额叶功能的改变，而不是内侧颞叶功能的改变。除了检查激素替代疗法对记忆的影响外，拟议的研究还将调查正常年龄相关的记忆损伤。具体来说，从具有代表性的社区样本中抽取健康的绝经后妇女，她们接受了长期的激素替代疗法，并将从未使用过激素替代疗法的年龄匹配的对照组与年轻的绝经前妇女进行识别记忆任务的比较。为了更好地分离HRT调节记忆功能的神经机制，将在记忆任务期间记录64个头皮部位的事件相关脑电位（ERPs）。此外，将收集被认为涉及额叶和内侧颞叶功能的神经心理学测量，并将其与记忆的行为和电生理指标相关联，作为额叶和内侧颞叶受累之间分离的聚合证据。总的来说，这项工作将作为一种手段，以更好地阐明与激素替代疗法和衰老相关的记忆变化类型，并提供与使用激素替代疗法的绝经后妇女的记忆效应相关的大脑行为关联的初步检查。