DEVELOPMENTAL TOXICITY OF METHYLMERCURY

甲基汞的发育毒性

• 批准号: 6178670
• 负责人: THOMAS W CLARKSON
• 金额: $ 19.55万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6178670
• 关键词: Osteichthyes; child (0-11); clinical research; disease /disorder proneness /risk; embryo /fetus toxicology; environmental toxicology; food contamination; human subject; longitudinal human study; methylmercury; nutrition related tag; pregnancy; seafood; seafood poisoning

DESCRIPTION: The main objective of the application is to better define the human health risks associated with prenatal and early postnatal exposure to methylmercury in fish. Subtle psychological and behavioral changes will be measured and related to the exposure of mothers during pregnancy. The study will be conducted on a cohort of 740 children from a population in the Seychelles Islands, whose diet consists primarily of large amounts of ocean fish. The application will extend the evaluation of developmental toxicity of methylmercury on the cohort to include the age of 7-8 years, which will make it feasible to compare results with those from studies of prenatally exposed infants in New Zealand and the Faeroe Islands. The population used in the longitudinal study presents a wide range in mercury levels so that the results can be applied in assessing the health risks in the U.S. population due to consumption of methylmercury in fish.

描述：应用程序的主要目标是更好地定义 与产前和产后早期接触有关的人类健康风险 鱼类中的甲基汞 微妙的心理和行为变化 测量并与母亲怀孕期间的接触有关。 研究 将对来自中国人口的740名儿童进行队列研究。 塞舌尔群岛，其饮食主要包括大量的海洋 鱼. 该应用将扩展发育毒性的评价 将7 - 8岁年龄组包括在内， 使其能够与产前研究的结果进行比较， 新西兰和法罗群岛的婴儿受到辐射。 人口使用 在纵向研究中，汞含量范围很广， 研究结果可用于评估美国的健康风险。 由于食用鱼类中的甲基汞而导致人口死亡。