PEDIATRIC STUDY CENTERS (PSCS) FOR A MRI STUDY OF NORMAL

儿科研究中心 (PSCS) 对正常儿童进行 MRI 研究

• 批准号: 6159274
• 负责人: Pauline A. Filipek
• 金额: $ 4.8万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2005-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6159274
• 关键词: adolescence (12-20); behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; biomedical resource; child (0-11); child behavior; clinical research; cognition; cooperative study; developmental neurobiology; diffusion; human subject; information systems; longitudinal human study; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; pediatrics; water

This is a multi-center study of normal structural and metabolic brain development in infants and children, being sponsored by NINDS, NIMH and NICHD. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) will be used to characterize brain development in relationship to behavior and cognition from ages 0 through 18 years, supplemented by diffusion tensor imaging (DTI) for ages 0 through 4 years. The project is planned for six years and involves a longitudinal design, repeated behavioral testing, and rescanning of subjects. This project will result in a representative, reliable and adequate database with which to characterize normal brain development, construct growth curves with which to evaluate individual brains, provide potential control data for studies of patients, and create developmentally-sensitive image analysis tools. A data sharing plan will be implemented to make this resource available to the medical and research community.

这是一项由NINDS、NIMH和NICHD赞助的关于婴儿和儿童正常结构和代谢大脑发育的多中心研究。磁共振成像(MRI)和磁共振波谱(MRS)将被用来表征0到18岁之间的大脑发育与行为和认知的关系，并辅之以0到4岁的扩散张量成像(DTI)。该项目计划六年，包括纵向设计、重复的行为测试和对受试者的重新扫描。该项目将产生一个具有代表性的、可靠的和足够的数据库，用于描述正常大脑发育的特征，构建用于评估个体大脑的生长曲线，为患者研究提供潜在的对照数据，并创建对发育敏感的图像分析工具。将实施一项数据共享计划，使医疗和研究界能够获得这一资源。