EFFECTS OF ORAL AND SYSTEMIC DISEASE ON QUALITY OF LIFE

只有当“下游”干预措施得以实施以控制炎症，从而改善患者和人群的健康时，炎症疾病中心基础生物学发现的最终价值才会显现出来。在这种情况下，人类健康包括延长寿命和提高生活质量（QoL），这是《2000年健康人倡议》所规定的卫生保健系统的两个目标。然而，直到最近，测量与口腔健康相关的生活质量的可靠和有效的方法才得到广泛应用，结果是评估口腔健康干预措施的生活质量结果的方法仍处于起步阶段。对于本中心的使命来说，一个重要的领域是局部（口腔）疾病和全身性疾病对人类健康的潜在协同效应，尽管目前缺乏方法学工作来评估这种与任何一种特定疾病（即口腔疾病）的联合效应。口腔健康相关的生活质量)或通用的生活质量仪器。本研究的目的是评估测量全身状况、口腔疾病及其治疗对生活质量的联合和协同作用的最佳方法。本研究将使用口腔健康影响简表（OHIP-14）测量口腔健康相关的生活质量，并使用医学结果研究简表健康调查（SF-36）测量遗传生活质量。这些问卷将由130名患有晚期牙病并表示有意最终拔除这些牙齿并放置全口义齿的（终末期牙列）患者完成。在基线、4周、26周和52周进行生活质量测量，并从治疗记录中提取同期治疗和临床状态。将对数据进行分析，以确定口服生活质量和普通生活质量的心理测量独立性。具体目标将首先通过横断面分析来探讨，其中生活质量测量将是因变量，口腔状况（目标1）或牙科治疗（目标2）将是因变量。然后，我们的研究假设将使用纵向数据进行分析，使用重复的方差测量进行分析。

The ultimate value of fundamental biological discoveries from the Center for Inflammatory Disorders will become apparent only when "downstream" interventions are implemented to control inflammation, thereby improving the health of patients and population. In this context, human health includes both extension of lifespan and enhancement of Quality of Life (QoL)-two objectives of the health care system enshrined in the Healthy People 2000 initiative. However, it is only recently that reliable and valid methods for measuring oral health related QoL have become widely available, with the consequence that methods for evaluate quality of life outcomes from oral health interventions remain in their infancy. One area that is important to this Center's mission is the potential for synergistic effects of local (oral) and systemic disease on human health, although there is a lack of methodological work to evaluate such joint effects with either disease specific (ie. oral health related QoL) or generic QoL instruments. The aim of this study is to evaluate methods that are optimal for measuring joint and synergistic effects on systemic conditions, oral disease and its treatment on quality of life. This study will measure oral health related QoL using the short form Oral Health Impact Profile (OHIP-14) and genetic QoL using the Medical Outcomes Study short-form health survey (SF-36). These questionnaires will be completed by 130 (terminal dentition) patients who have advanced dental disease and who have expressed an intent for ultimate removal of those teeth and placement with complete dentures. QoL measures will be administered at baseline, 4 weeks, 26 weeks and 52 weeks, and concurrent treatments and clinical status will be abstracted from treatment records. The data will be analyzed for psychometric independence of oral and generic QoL. Specific aims will be explored initially through cross- sectional analyses, where QoL measures will be the dependent variables and oral status (aim 1) or dental treatments (aim 2) will be the dependent variables. our study hypotheses will then be analyzed using longitudinal data analyzed using repeated measures of variance.