LONGITUDINAL ADOPTION STUDY OF ADOLESCENT SUBSTANCE EXPERIMENTATION

青少年物质实验的纵向采用研究

• 批准号: 6104174
• 负责人: ROBIN P CORLEY
• 金额: $ 16.71万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104174
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavior disorders; behavioral /social science research tag; behavioral genetics; child (0-11); child foster care /adoption; clinical research; family genetics; family structure /dynamics; gene environment interaction; human subject; marijuana abuse; socioenvironment; substance abuse related disorder; tobacco abuse; twin /multiplet

The primary objective of this proposal is to assess genetic and environmental influences on experimentation with tobacco, alcohol, marijuana, and other drugs using a longitudinal adoption design. This study builds on more than 20 years of data collected as part of the Colorado Adoption Project (CAP), and focuses on the transmission of substance use and antecedent behaviors such as conduct disorder symptoms, other behavioral problems, and academic achievement difficulties. Close integration of measures collected as part of two other components from this center application, Component 2 (Adolescent Substance Abuse), and Component 4 (Adolescent Twins), will facilitate cross-component analysis of substance use and related behavioral problems. Combined analysis of data from this component and component 2 will explicitly test the hypothesis that familial transmission parameters for severe substance abuse and for experimentation in adolescence are distinct. Combined analysis of data from this component and component 4 will test the importance of a specific twin shared environmental parameter that includes cohort effects. By the end of the grant cycle, substance experimentation histories through age 17 will have been obtained from more than 200 adopted probands and 100 genetically unrelated older siblings and 200 matched control early adulthood. In addition, 90 younger siblings of each type will have been followed longitudinally at least to age 15. Some information on substance use by the biological and rearing parents of the probands is currently available; additional information on substance use by rearing parents of the adopted and control probands will be collected. Information on temperament, personality, cognitive abilities, achievement, and adjustment, as well as individual perceptions of the family environment, is available for all CAP participants. Multivariate genetic analyses of combined data sets will also be used to test hypotheses concerning genetic and environmental mediation of the association between behavioral problems, substance experimentation, and achievement.

该提案的主要目标是评估遗传和 环境对烟草，酒精， 大麻和其他毒品使用纵向收养设计。 这 这项研究基于20多年来收集的数据， 科罗拉多收养项目（CAP），重点是传播 物质使用和先前行为，如行为障碍 症状、其他行为问题和学业成绩 困难 密切结合作为两个其他方案的一部分收集的措施， 此中心应用程序的组件，组件2（青少年 物质滥用）和组成部分4（青少年双胞胎），将促进 物质使用和相关行为的跨成分分析 问题 本组件和组件数据的合并分析 2将明确测试的假设，家庭传播参数 严重的药物滥用和青春期的实验， 与众不同本构成部分和构成部分4的数据合并分析 将测试一个特定的双胞胎共享环境的重要性， 包括队列效应的参数。 在资助周期结束时， 将从200多名被收养的儿童中获得 先证者和100名遗传无关的年长兄弟姐妹和200名匹配的 控制成年早期。 此外，每种类型的90个弟弟妹妹 将被纵向跟踪至少到15岁。 一些 关于儿童的亲生父母和抚养父母使用药物的资料 先证者目前可用;关于物质的其他信息 被收养和对照先证者的养育父母使用， 收集。 关于气质，个性，认知能力， 成就和调整，以及个人对 家庭环境，适用于所有CAP参与者。 多元 组合数据集的遗传分析也将用于测试 关于遗传和环境介导的假说 行为问题、物质实验和 成就