PARASITIC DISEASES RESEARCH IN AFRICA

修改后的申请旨在建立一个国际 非洲寄生虫病合作研究计划。这个 目标是应用现代生物医学和流行病学工具来研究 血吸虫病中宿主-寄生虫关系的特定方面， 班氏丝虫病和包虫病。建议的相互依存 多学科研究将解决1)特定的决定因素 感染结局的特点和2)这方面的利用 理解以偏爱人类主人。一系列的田野、人口 建议进行基础研究和实验室研究。该应用程序是 分三个项目组织，解决每个传染性疾病的特定方面 疾病和两个核心，以协调行政和免疫 这些研究的各个方面。这些项目的主要目标包括 以下方面的研究： 项目1：检测对嗜血杆菌的免疫反应 感染及其与年龄、感染强度和疗效的关系 化疗的结果。 项目2：母体感染班氏念珠菌对丝虫病的影响 子代的免疫病理学。 项目3：确定免疫学的自然病史和谱系 对已定义的原生和重组寄生虫抗原的反应 包虫病。 该计划是长期合作努力的自然结果 在美国和肯尼亚的调查人员之间。它将提供 形成控制战略所需的信息，并进一步 培训和技术转让的机会。

This revised application aims at establishing an international collaborative research program on Parasitic Diseases in Africa. The objective is to apply modern biomedical and epidemiological tools to study specific aspects of host-parasite relationship in schistosomiasis, bancroftian filariasis and echinococcosis. The proposed interdependent and multidisciplinary studies will address 1) the determinants of specific features of the outcome of infection and 2) the utilizations of this understanding to favor the human host. A series of field, population based and laboratory investigations are proposed. The application is organized in three projects addressing specific aspects of each infectious disease and two cores to coordinate the administrative and immunological aspects of these studies. The major objectives of these projects include studies of: Project 1: Examination of the immune response to S. haematobium infection and its relationship to age, intensity of infection and effect of chemotherapy. Project 2: Effect of W. bancrofti infection in mothers on filariasis immunopathology in offspring. Project 3: Determine the natural history and spectrum of immunologic responses to defined native and recombinant parasite antigens in echinococcosis. The program is a natural outcome of long standing collaborative efforts between U.S.-based and Kenyan-based investigators. It will provide information necessary to shape control strategies and further opportunities for training and technology transfer.