PARASITIC DISEASES RESEARCH IN AFRICA

本修订后的申请旨在建立一个国际 非洲寄生虫病合作研究计划。 的 目标是应用现代生物医学和流行病学工具来研究 血吸虫病宿主与寄生虫关系的具体方面， 班克罗夫特丝虫病和包虫病。 拟议的相互依存 多学科研究将解决 1) 具体的决定因素 感染结果的特征以及 2) 该方法的用途 理解有利于人类宿主。 一系列字段、人口 建议进行基础研究和实验室研究。 该应用程序是 分为三个项目，针对每种传染病的具体方面 疾病和协调行政和免疫学的两个核心 这些研究的各个方面。 这些项目的主要目标包括 研究： 项目 1：检查埃及沙门氏菌的免疫反应 感染及其与年龄、感染强度和效果的关系 化疗。 项目2：母亲班氏丝虫感染对丝虫病的影响 后代的免疫病理学。 项目 3：确定免疫学的自然史和谱 对特定天然和重组寄生虫抗原的反应 包虫病。 该计划是长期合作努力的自然结果 美国和肯尼亚调查人员之间的调查。 它将提供 制定控制策略所需的信息并进一步 培训和技术转让的机会。

This revised application aims at establishing an international collaborative research program on Parasitic Diseases in Africa. The objective is to apply modern biomedical and epidemiological tools to study specific aspects of host-parasite relationship in schistosomiasis, bancroftian filariasis and echinococcosis. The proposed interdependent and multidisciplinary studies will address 1) the determinants of specific features of the outcome of infection and 2) the utilizations of this understanding to favor the human host. A series of field, population based and laboratory investigations are proposed. The application is organized in three projects addressing specific aspects of each infectious disease and two cores to coordinate the administrative and immunological aspects of these studies. The major objectives of these projects include studies of: Project 1: Examination of the immune response to S. haematobium infection and its relationship to age, intensity of infection and effect of chemotherapy. Project 2: Effect of W. bancrofti infection in mothers on filariasis immunopathology in offspring. Project 3: Determine the natural history and spectrum of immunologic responses to defined native and recombinant parasite antigens in echinococcosis. The program is a natural outcome of long standing collaborative efforts between U.S.-based and Kenyan-based investigators. It will provide information necessary to shape control strategies and further opportunities for training and technology transfer.