COMPREHENSIVE CANCER CENTER CORE SUPPORT GRANT

在过去的五年里，杜克综合癌症中心 继续履行其使命，成为一个成熟的“矩阵+”组织。 五名年轻的调查员被直接征聘到调查科， 细胞生长、调节和肿瘤发生。 总体而言，整个征聘过程 杜克大学医学中心促进了癌症的生长， 中心包括255名成员谁参加12个方案。 癌症 中心的方案已进行重组，以更准确地反映 成员之间的互动，以及更有效地促进 他们的合作。 在结构方面建立了新的方案 生物学，宿主抗性和白细胞生物学，多学科临床 试验和癌症预防，检测和控制研究。 共享 资源现在包括23个设施，促进实验室和 临床癌症研究。 在蛋白质方面建立了新的设施 结晶、二维凝胶分析、免疫细胞化学和体细胞 杂交方法 在肽方面的资源已大大加强 测序，分子图形，核磁共振，共聚焦 显微镜、住院临床研究、骨髓移植和 生物统计学 癌症中心的隔离设施在2004年增加了一倍。 尺寸 新的建设已经开始，将提供40,000 NSF的 为癌症中心研究人员提供更多的空间， 连接科学 发展基金的使用使征聘工作得以进行， 细胞生长，调节和肿瘤发生部分，一个戏剧性的 扩大生物统计学，启动癌症预防，检测 和控制研究计划，招募心理社会调查， 加强共享资源，提供临时资金， 支持试点项目。 在核心补助金的帮助下，杜克 调查人员在过去五年中发表了4,500多篇论文， 这些年来对细胞调节领域做出了重大贡献， DNA复制，结构生物学，病毒肿瘤学，白细胞生物学， 神经肿瘤学，自体骨髓移植，妇科 肿瘤学，多学科治疗，临床应用 造血生长因子和癌症筛查。 请求支持 高级领导者、项目负责人、行政管理、共享资源和 全面实施杜克战略计划的发展 综合癌症中心。

During the last five years the Duke Comprehensive Cancer Center has continued to fulfill its mission, maturing as a "matrix-plus" organization. Five young investigators have been recruited directly into the Section of Cell Growth, Regulation and Oncogenesis. Overall, recruitment throughout the Duke University Medical Center has facilitated growth of the Cancer Center to include 255 members who participate in 12 Programs. The Cancer Center's Programs have been reorganized to reflect more accurately interactions between members, as well s to facilitate more effectively their collaboration. New Programs have been established in Structural Biology, Host Resistance and Leukocyte Biology, Multidisciplinary Clinical Trials and Cancer Prevention, Detection and Control Research. Shared Resources now include 23 facilities that facilitate both laboratory and clinical cancer research. New facilities have been established in protein crystallization, 2-D gel analysis, immunocytochemistry and somatic cell hybridization. Resources have been substantially strengthened in peptide sequencing, molecular graphics, nuclear magnetic resonance, confocal microscopy, in-patient clinical research, bone marrow transplantation and biostatistics. The Cancer Center Isolation Facility has been doubled in size. New construction has been initiated that will provide 40,000 NSF of additional space for Cancer Center investigators in fundamental and bridging sciences. Use of development funds has permitted recruitment into the Section of Cell Growth, Regulation and Oncogenesis, a dramatic expansion of biostatistics, initiation of the Cancer Prevention, Detection and Control Research Program, recruitment in psychosocial investigation, strengthening of Shared Resources, provision of interim funding and the support of pilot projects. Facilitated by the Core Grant, Duke investigators have published greater than 4,500 papers during the last five years that have contributed substantially to the fields of cell regulation, DNA replication, structural biology, viral oncology, leukocyte biology, neurooncology, autologous bone marrow transplantation, gynecologic oncology, multidisciplinary treatment, clinical application of hematopoietic growth factors and cancer screening. Support is requested for Senior Leaders, Program Leaders, Administration, Shared Resources and Development to implement fully the strategic plan for the Duke Comprehensive Cancer Center.