CORE--MOUSE PATHOLOGY

拟议方案的所有三个项目都涉及对 靶向基因导致的功能丧失突变的后果 对小鼠的肿瘤抑制基因进行编码。这些研究需要专家和 对大量样本(胚胎、 组织和肿瘤)，以研究表型表现对 正常的小鼠发育和/或促成肿瘤形成。这个 对项目开发至关重要的诊断程序 包括宏观解剖检查、显微组织学、原位 杂交和免疫组织化学。 这个核心设施的目的是通过一个 经验丰富的病理学家结合了他独特的背景和专业知识 人类临床病理学和小鼠发育和病理学， 包括肿瘤的发生。核心的质量控制将通过以下方式确保 优化、规范和精简所涉程序，以 [迅速、高效地提供口译。与以下项目积极互动 计划参与者是预期的，并应加强 开发涉及鼠标模型的项目。

All three projects of the proposed program involve the study of the consequences of loss-of-function mutations generated by targeting of genes encoding tumor suppressors in mice. These studies require expert and efficient pathological analyses of large number of specimens (embryos, tissues and tumors), to investigate phenotypic manifestations affect normal murine development and/or contributing to tumorigenesis. The diagnostic procedures that are central to the development of the program include macroscopic anatomic examination, microscopic histology, in situ hybridization and immunohistochemistry. The aim of this Core facility is to provide murine pathology serve by an experienced pathologist combining uniquely in his background expertise in both human clinical pathology and mouse development and pathology, including oncogenesis. Quality control in the Core will be secured by optimizing, standardizing nd streamlining the procedures involved, to [provide interpretations rapidly and efficiently. Active interactions with the program participants are anticipated and should enhanced the development of the projects involving mouse models.