Syphilis self-testing to expand test uptake among men who have sex with men (SST)

梅毒自我检测以扩大男男性行为者的检测率（SST）

• 批准号: MR/T003995/1
• 负责人: Joseph Tucker
• 金额: $ 18.97万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT003995%2F1
• 关键词: Syphilis; self; testing; expand; test

Across a wide range of resource-constrained settings, syphilis infection causes substantial morbidity. Syphilis increases the risk of acquiring and transmitting HIV infection, but is frequently asymptomatic. Many men who have sex with men (MSM) with high risk sexual behaviours are unable to receive syphilis testing because of centralized testing sites and stigma associated with testing sites. One way to increase syphilis test uptake among MSM is syphilis self-testing. Syphilis self-testing has a person use a test kit and interpret their own test result. HIV self-testing programs have already introduced the concept of self-testing to MSM and created an infrastructure to distribute and measure uptake of self-testing. Sensitive and specific syphilis self-test kits are available and can be used to detect syphilis infection, similar to treponemal serologies commonly used in clinical practice. Syphilis self-testing could decentralize testing and decrease stigma associated with testing. Our nationwide study found that 174/699 (24.9%) of a Chinese MSM sample already use syphilis self-test kits. We have organized five randomized controlled trials focused on increasing HIV test uptake among MSM.To date, there have been no studies evaluating the efficacy of MSM syphilis self-testing compared to facility-based testing. Our long-term goal is to organize a large two-country study to evaluate if self-testing can improve syphilis diagnosis and treatment. As a first step, we will finalise and pilot an intervention to promote syphilis self-testing and linkage to clinical services. This will establish a strong foundation for a randomized controlled trial if the pilot is deemed effective.The study will take place in Guangzhou (China) and Harare (Zimbabwe), two settings with a high burden of syphilis infection, strong linkages to MSM community organizations and health services, and ongoing HIV self-testing programs. Many research tools and methods developed to measure HIV self-testing can be directly applied in this study. We expect that our China-Africa project would facilitate adoption of the intervention in both other Chinese provinces as well as other less-developed African countries. This project will synergize with and benefit from ongoing China-Africa STI collaboration.

在各种资源受限的环境中，梅毒感染导致大量发病率。梅毒增加了感染和传播艾滋病毒的风险，但通常没有症状。许多有高风险性行为的男男性行为者（MSM）无法接受梅毒检测，因为检测地点集中，而且与检测地点有关。增加男男性接触者梅毒检测的一种方法是梅毒自检。梅毒自检是一个人使用检测试剂盒并解释自己的检测结果。艾滋病毒自我检测项目已经向男男性行为者介绍了自我检测的概念，并建立了一个基础设施来分发和衡量自我检测的接受情况。有敏感和特异性梅毒自检试剂盒，可用于检测梅毒感染，类似于临床实践中常用的密螺旋体血清学。梅毒自我检测可以分散检测，减少与检测相关的耻辱感。我们的全国性研究发现，中国MSM样本中174/699（24.9%）已经使用梅毒自检试剂盒。我们组织了五项随机对照试验，重点是增加男男性行为者接受艾滋病毒检测。迄今为止，还没有研究评估男男性接触者梅毒自检与机构检测的效果。我们的长期目标是组织一项大型的两国研究，以评估自我检测是否可以改善梅毒的诊断和治疗。作为第一步，我们将确定和试行一项干预措施，以促进梅毒自检和与临床服务的联系。如果试验被认为有效，这将为随机对照试验奠定坚实的基础。该研究将在广州（中国）和哈拉雷（津巴布韦）进行，这两个地区梅毒感染负担高，与男男性行为者社区组织和卫生服务联系密切，并且正在进行艾滋病毒自我检测项目。许多HIV自我检测的研究工具和方法可以直接应用于本研究。我们希望我们的中非项目能够促进中国其他省份以及非洲其他欠发达国家采用干预措施。该项目将与正在进行的中非科技创新合作形成合力，并从中受益。

项目成果

Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men who have sex with men in China: A multiarm randomized controlled trial.

• DOI: 10.1371/journal.pmed.1003930
• 发表时间: 2022-03
• 期刊: PLoS medicine
• 影响因子: 15.8
• 作者: Wang C;Ong JJ;Zhao P;Weideman AM;Tang W;Smith MK;Marks M;Fu H;Cheng W;Terris-Prestholt F;Zheng H;Tucker JD;Yang B
• 通讯作者: Yang B

Syphilis self-testing to expand test uptake among men who have sex with men: a theoretically informed mixed methods study in Zimbabwe.

• DOI: 10.1136/sextrans-2020-054911
• 发表时间: 2022-05
• 期刊: Sexually transmitted infections
• 影响因子: 3.6
• 作者: Sri-Pathmanathan C;Nhamo D;Mamvuto T;Chapwanya G;Terris-Prestholt F;Mahaka I;Marks M;Tucker JD
• 通讯作者: Tucker JD