OPIOID INVOLVEMENT IN ALCOHOL DRINKING

描述：这项研究计划解决了这样的假设 酒精诱导的阿片系统激活是一种神经生物学 导致高酒精饮酒的机制。这样做的目的是 建议确定受体选择性阿片拮抗剂是否 能够阻止高酒精饮酒的开始和维持 在有选择地为酒精偏好而饲养的大鼠中。为了实现这一目标， 将追求以下具体目标：1.确定慢性 单独给药MU和Delta受体选择性拮抗剂 两者合用，可减少大鼠饮酒后的饮酒 有选择地为酒精偏好而培育的。 2.确定长期给药是MU还是Delta 受体选择性拮抗剂防止再次饮酒 选择性地停止大鼠的慢性消费(复发) 生来就喜欢喝酒。 3.确定长期给药是MU还是Delta 受体选择性拮抗剂预防小鼠饮酒的启动 有选择地培育出偏爱酒精的大鼠。 拟议的实验将确定Mu和Delta的效力。 受体选择性拮抗剂在减少酒精摄入量和意志中的作用 确定这些拮抗剂是否主要减少酒精的摄入量 与食物、水的摄入量相比，另一种首选解决方案。 实验将使用酒精喜好(P)的大鼠进行。 和高酒精饮酒(HAD)线，这是非常适合测试 有可能减少酒精摄入量的药剂的功效。

DESCRIPTION: This research plan addresses the hypothesis that alcohol-induced activation of the opioid system is a neurobiological mechanism that contributes to high alcohol drinking. The goal of this proposal is to determine whether receptor-selective opioid antagonists are capable of blocking the initiation and maintenance of high alcohol drinking in rats selectively bred for alcohol preference. To achieve this goal the following specific aims will be pursued: 1. Determine whether chronic administration of a mu and a delta receptor-selective antagonist, alone and in combination, attenuates alcohol drinking after drinking has begun in rats selectively bred for alcohol preference. 2. Determine whether chronic administration of a mu or a delta receptor-selective antagonist prevents reinitiation of alcohol drinking following cessation of chronic consumption (relapse) in rats selectively bred for alcohol preference. 3. Determine whether chronic administration of a mu or a delta receptor-selective antagonist prevents the initiation of alcohol drinking in rats selectively bred for alcohol preference. The proposed experiments will determine the potency of mu and delta receptor-selective antagonists in attenuating alcohol intake and will determine whether these antagonists primarily reduce the intake of alcohol compared with the intake of food, water, and another preferred solution. The experiments will be conducted using rats of the alcohol-preferring (P) and high alcohol drinking (HAD) lines which are well suited for testing the efficacy of agents that have the potential to reduce alcohol intake.