HIGH RESOLUTION MASS SPECTROMETER

这项提议的目的是取代17岁的Kratos MS5O 普渡大学磁扇型高分辨率质谱仪 拥有最先进的磁扇形高分辨率质谱仪。 克瑞托斯MS50是普渡大学唯一的高分辨率质谱仪， 而它的年龄以及对它的沉重要求导致了它的失败 在定期的基础上，从而危及一个大型的 NIH资助的调查人员在校园内的数量。除了更多 比MS50更可靠，这是一种新的磁扇区高分辨率质量 光谱仪将提供与扩展质量的MS50相比的优势 范围，电喷雾电离能力，它将提供合适的 高效液相色谱-质谱联用平台新仪器将设在本部门 药物化学和分子药理学，并将合并 进入现在的校园范围的质谱学中心(CWMSC)。因此， 它将为校园内70多个不同的研究小组提供服务 20个学术部门。由现在资助的质谱仪 应用程序将由现有策略管理，该策略适用于 目前的Kratos MS50仪器。质谱学监督 委员会将与适当的销售代表会面，审查 候选仪器的规格和性能，并将使 最终的选择。此外，该委员会还将选择测试 样本，检查测试样本结果，并最终协调 仪器的安装。全校弥撒的负责人 光谱中心、部门质谱学操作员和 电子技术员将与安装工程师一起成为 尽可能熟练地维护和操作新的 乐器。该工具将由 药物化学与分子药理学系 化学系、普渡癌症中心和向用户收费 基于执行服务所需的时间。收费标准将是 由系主任与院系协商后确定 负责质谱学的部门代表 实验室和CWMSC主任。

The purpose of this proposal is to replace the 17 year-old Kratos MS5O magnetic sector high resolution mass spcctrometer at Purdue University with a state of the art magnetic sector high resolution mass spectrometer. The Kratos MS50 is the only high resolution mass spectrometer at Purdue, and its age as well as the heavy demands placed on it cause it to fail on a regular basis, thus jeopardizing the research progress of a large number of NIH-funded investigators across campus. Besides being more reliable than the MS50, a new magnetic sector high resolution mass spectrometer will offer the advantages vs. the MS50 of extended mass range, eletrospray ionization capabilities, and it will provide a suitable platform for HPLC-MS. The new instrument will be located in the Department of Medicinal Chemistry and Molecular Pharmacology and will be incorporated into the present Campus-wide Mass Spectrometry Center (CWMSC). As such, it will serve over 70 different research groups across campus located in 20 academic departments. The mass spectrometer funded by the present application will be administered by an existing policy which applies to the current Kratos MS50 instrument. The Mass Spectrometry Oversight Committee will meet with the appropriate sales representatives, review the specifications and performance of the candidate instruments and will make the final selection. In addition, this committee will select test samples, examine the test sample results and ultimately coordinate the installation of the instrument. The Director of the Campus-wide Mass Spectrometry Center, the Departmental Mass Spectrometry Operator and the Electronics Technician will work with the Installation Engineer to become as proficient as possible in the maintenance and operation of the new instrument. The instrument will be supported financially by the Department of Medicinal Chemistry and Molecular Pharmacology, the Department of Chemistry, the Purdue Cancer Center, and by charges to users based on the time required to perform the service. The charge rate will be set by the Department Head in consultation with the Faculty Representative of the Department responsible for the Mass Spectrometry Laboratory and the Director of the CWMSC.